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Cancer Immune Checkpoints

Cancer Immune Checkpoints

Increasing knowledge of how cancer cells escape immune destruction has significantly driven the evolution of cancer immunotherapy. In particular, studies describing how different immune checkpoints, including the PD-1 and CTLA-4 pathways, function to attenuate T cell antitumor activity have revealed novel opportunities for therapeutic intervention. Researchers have made promising strides in inhibiting these checkpoints to unleash the T cells’ tumor-killing potential. Given that both radiotherapy and chemotherapy can also mobilize antitumor T cells, there is great excitement that checkpoint inhibition and other immunomodulatory approaches can be combined with conventional modalities to maximize clinical outcomes for a number of malignancies.

Highlighted Products

    

VPD-1 antibody (GTX20256)

 

CTLA4 antibody  (GTX75812)

CD134 antibody [OX86] (GTX74991)

 
 

Arginase1 antibody (GTX109242)

 

iNOS antibody (GTX130246)

FOXP3 antibody  (GTX80283)

 
 

TNF alpha antibody (GTX110520)

 

IFN gamma antibody (GTX31185)

 

CD80 antibody  (GTX84701)

 
 

CD86 antibody  (GTX41787)

 

CD137 antibody [17B5] (GTX42758)

 

CD137L antibody (GTX117355)

 
 
 

CD276 Antibody (GTX42152)

CD28 antibody (GTX33959)

 

ICOS antibody (GTX129570)

 
 
 

CD525 antibody  (GTX42201)

 

TIM-3 antibody  (GTX54054)

LAG3 antibody (GTX42244)

 
 

CD40 antibody (GTX101447)

CD4 antibody (GTX44531)

   

 

Cat.No. Product Name Host&Clonality Reactivity Applications  
GTX104763 PD-L1 antibody Rb pAb Hu ICC/IF, IHC-Fr, IHC-P, WB    
 GTX42160 PD-L1 antibody [MIH6] Rat mAb Ms FACS, IHC-Fr, IP  
GTX20256 PD1 antibody [NAT105] Ms mAb Hu, Ms FACS, ICC/IF, IHC, IHC-Fr, IHC-P, IP, WB
GTX85449 PD-L2 antibody Rb pAb Hu, Ms, Rat ELISA, IHC-P, WB  
GTX42170 PD-L2 antibody [MIH14] Ms mAb Hu FACS, IHC-Fr  
GTX109242 Arginase 1 antibody Rb pAb Hu, Ms, Rat ELISA, FACS, ICC/IF, IHC-Fr, IHC-P, IP, WB  
GTX130246 iNOS antibody Rb pAb Ms, Rat ICC/IF, IHC-P, WB  
GTX88996 B7-H4 antibody, Internal Gt pAb Hu WB  
GTX84720 CD4 antibody [10B5] Ms mAb Hu, Dog, Mk, Rat WB
GTX44531 CD4 antibody [GK1.5] Rat  mAb Ms ELISA, FACS, ICC/IF, IHC-Fr, IHC-P, IP, WB
GTX76318 CD4 antibody [W3/25] Ms mAb Rat FACS, IHC-Fr, IHC-P
GTX42439 CD134 antibody [OX-40] Ms mAb Rat FACS, IHC-Fr, IP
GTX74995 CD134 antibody [OX86] Rat mAb Ms, Rat Blocking, FACS, IHC-Fr
GTX42437 CD137 antibody [17B5] (Low endotoxin, azide free) Ham mAb Ms FACS, Functional Assay  
GTX117355 4-1BBL / CD137L antibody [N2C3] Rb pAb Hu IP, WB  
GTX42201 CD252 antibody [OX-89] Rat mAb Ms FACS, IHC-Fr  
GTX42152 CD276 antibody [MIH42] Ms mAb Hu FACS, IHC-Fr
GTX33959 CD28 antibody Rb pAb Hu, Ms, Rat FACS, IHC-P  
GTX80197 CD28 antibody [CD28.2] (FITC) Ms mAb Hu, NHuPrm FACS, ICC/IF, IHC-Fr, IP, WB, Functional Assay  
GTX42131 CD28 antibody [YTH913.12] (Low endotoxin, azide free) Rat mAb Hu FACS, IHC-Fr, IP, Functional Assay
GTX101447 CD40 antibody Rb pAb Hu ICC/IF, IHC-Fr, IHC-P, WB
GTX44541 CD40 antibody [3/23] (Low endotoxin, azide free) Rat mAb Ms ELISA, FACS, IHC-Fr, Functional Assay  
GTX13546 CD40L / CD154 antibody [5F3] Ms mAb Hu FACS  
GTX84701 CD80 antibody [2B11] Ms mAb Hu ICC/IF, IHC-P, WB
GTX41787 CD86 antibody [24F] Ms mAb Rat FACS, IHC-Fr, IP  
GTX74650 CD86 antibody [BU63] Ms mAb Hu FACS, ICC/IF, IHC, IHC-Fr, IP, WB
GTX75812 CTLA4 antibody [WKH203] (Azide free) Ms mAb Hu, Rat ELISA, FACS  
GTX80283 FOXP3 antibody [3G3] Ms mAb Hu, Ms FACS, WB  
GTX107737 FOXP3 antibody [C3], C-term Rb pAb Hu, Ms ICC/IF, IHC-P, IP, WB
GTX89934 FOXP3 antibody, C-term Gt pAb Hu FACS, ICC/IF, IHC-P, WB  
GTX127352 Galectin 9 antibody Rb pAb Hu IHC-P, WB
GTX31185 Interferon gamma antibody Rb pAb Rat ELISA, IHC, WB  
GTX15624 Interferon gamma antibody [2G1] Ms mAb Hu, Ms ELISA, WB, sELISA  
GTX130513 IL10 antibody Rb pAb Hu ELISA, WB  
GTX101138 IL2 antibody Rb pAb Hu IHC-P, WB  
GTX108495 IL2 Receptor beta antibody [C3], C-term Rb pAb Hu ICC/IF, IHC-P, WB  
GTX42485 Interferon gamma Receptor 1 antibody [BB1E2] Ms mAb Hu, Bov ELISA, FACS, IHC-Fr, WB  
GTX53343 Interferon gamma Receptor 2 antibody [7A25] Ham mAb Ms Neut, WB  
GTX76000 KIR family antibody [NKVFS1] Ms mAb Hu ELISA, FACS, IP, WB  
GTX42244 LAG3 antibody [C9B7W] (Low endotoxin, azide free) Rat mAb Ms FACS, Functional Assay
GTX81605 LAG3 antibody, Internal Rb pAb Hu, Ms FACS, IHC-P, WB  
GTX37456 MDC antibody Rb pAb Ms, Rat ELISA, IHC-P, WB  
GTX83552 STAT1 antibody [4H9] Ms mAb Hu, Dog, Mk ICC/IF, IHC-P, WB
GTX110587 STAT3 antibody [C2C3], C-term Rb pAb Hu, Ms FACS, ICC/IF, IHC-P, WB  
GTX104616 STAT3 antibody [C3], C-term Rb pAb Hu, Ms, Rat, plnt ICC/IF, WB  
GTX108701 TBX21 antibody [N1C2] Rb pAb Hu IHC-P, WB  
GTX45121 TGF beta 1 antibody Rb pAb Hu, Ms, Rat IHC, IHC-Fr, WB
GTX130023 TGF beta 1 antibody Rb pAb Hu, Ms WB   
GTX54117 TIM-3 antibody Rb pAb Hu WB  
GTX54054 TIM-3 antibody [RMT3-23] (Low endotoxin, azide free) Rat mAb Ms FACS, ICC/IF, IHC-Fr, IHC-P, Functional Assay
GTX110520 TNF alpha antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC-P, WB  
GTX28349 TNF alpha antibody [F6C5] Ms mAb Hu ELISA, IHC-Fr, IHC-P

 

 

Pathways
Wnt Pathway

Wnt Pathway

Wnt proteins are secreted morphogens that are required for various developmental processes.
Literature
Poster - Cancer Signaling

Poster - Cancer Signaling

Download the latest version of GeneTex's cancer signaling poster
Literature
Pamphlet - Hot Products

Pamphlet - Hot Products

Download the latest version of GeneTex's pamphlet of hot products.
Literature
Pamphlet - Antibodies for Cancer Research

Pamphlet - Antibodies for Cancer Research

Download the latest version of GeneTex's pamphlet of antibodies for cancer research
Literature
Flyer - Cancer Immune Checkpoints

Flyer - Cancer Immune Checkpoints

Download the latest version of GeneTex's cancer immune checkpointss flyer
Literature
Poster - Cancer Signaling

Poster - Cancer Signaling

Download the latest version of GeneTex's cancer signaling poster
Literature
Pamphlet - Hot Products

Pamphlet - Hot Products

Download the latest version of GeneTex's pamphlet of hot products.
Literature
Pamphlet - Antibodies for Cancer Research

Pamphlet - Antibodies for Cancer Research

Download the latest version of GeneTex's pamphlet of antibodies for cancer research
Literature
Flyer - Cancer Immune Checkpoints

Flyer - Cancer Immune Checkpoints

Download the latest version of GeneTex's cancer immune checkpointss flyer