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Hypoxia

The development of complex anatomical and physiological systems to maintain oxygen homeostasis was an essential process in the evolution of metazoans. Hypoxia, defined as an insufficient oxygen supply to tissues, elicits a cellular response that hinges on the stabilization of hypoxia-inducible factors (HIFs). These transcription factors are subsequently able to accumulate in the nucleus and bind to DNA at “hypoxia response elements” (HREs) and subsequently drive either the expression (or, perhaps indirectly, the repression) of hundreds of genes.

Highlighted Products

      

HIF1 alpha antibody [GT10211] (GTX628480)

 

HIF1 beta antibody (GTX128795)

HIF2 alpha antibody [GT125] (GTX632015)

 
 
 

CAIX antibody [GT12] (GTX70020)

 

Heme Oxygenase 1 antibody (GTX101147)

  

PHD2 antibody (GTX132293)

 
 
 

PKM antibody (GTX107977)

  

MMP2 antibody (GTX104577)

 

VEGF antibody (GTX102643)

  
 
 

VE-cadherin antibody [GT1369] (GTX633705)

 

mTOR antibody [C3], C-term (GTX101557)

 

AKT (pSer473) antibody (GTX128414)

 
 
 

PHD1 antibody (GTX123033)

 

PHD4 antibody (GTX116582)

 

VHL antibody (GTX101087)

 
 
 

PD-L1 antibody (GTX104763)

   
     

Hypoxia-inducible Factors

Cat. No. Product Name Host & Clonality Reactivity Applications  
GTX127309 HIF1 alpha antibody Rb pAb  Hu, Ms, Rat, Bov ICC/IF, IHC-Fr, IHC-P, IP, WB, ChIP assay   
GTX628480 HIF1 alpha antibody [GT10211] Ms mAb Hu ICC/IF, IHC-P, IP, WB  
GTX30105 HIF1 alpha antibody [H1alpha67] Ms mAb Hu, Ms, Mk, Pig, Rat, Yeast, Frt, NHuPrm, Rb, Shp, Bov, Bat, Xenopus ELISA, FACS, GSA, ICC/IF, IHC, IHC-Fr, IHC-P, IP, WB, ChIP assay, Activation  
GTX128795 HIF1 beta antibody Rb pAb  Hu, Ms ICC/IF, IHC-P, WB
GTX22771 HIF1 beta antibody [2B10] Ms mAb Hu, Ms, Rat, Fsh, NHuPrm, Xenopus GSA, ICC/IF, IHC, IHC-P, IP, WB
GTX30114 HIF2 alpha antibody Rb pAb  Hu, Ms, Mk, Rat, Fsh ICC/IF, IHC, IHC-P, WB   
GTX103707 HIF2 alpha antibody [N1N3] Rb pAb  Hu, Zfsh WB, ChIP assay  
GTX632015 HIF2 alpha antibody [GT125] Ms mAb Hu, Ms, Rat ICC/IF, IP, WB  
GTX130988 HIF3 alpha antibody Rb pAb  Hu WB  
GTX85702 HIF3 alpha antibody Rb pAb  Hu, Ms, Rat ELISA, ICC/IF, IHC-P, WB  

 

HIF Synthesis

Cat. No. Product Name Host & Clonality Reactivity Applications  
GTX121937 AKT antibody [N3C2], Internal Rb pAb  Hu, Ms, Rat ICC/IF, IHC, IHC-Fr, IHC-P, IP, WB   
GTX128414 AKT (phospho Ser473) antibody Rb pAb  Hu, Ms, Rat IHC-P, IP, WB  
GTX111068 PI3 kinase p85 alpha antibody [N2C1], Internal Rb pAb  Hu, Ms, Rat IHC-P, IP, WB  
GTX64311 PI3 kinase p85 beta antibody [GT1119] Rb mAb Hu, Rat FACS, ICC/IF, IHC-P, WB  
GTX132597 PI3 kinase p85 (phospho Tyr467)/p55 (phospho Tyr199) antibody Rb pAb  Hu, Ms, Rat WB  
GTX107779 PI3 kinase p55 gamma antibody Rb pAb  Hu, Rat IHC-P, WB  
GTX100462 PI3 kinase p110 alpha antibody Rb pAb  Hu, Ms ICC/IF, IHC-P, WB
GTX111173 PI3 kinase p110 beta antibody [N3C2], Internal Rb pAb  Hu, Ms, Rat ICC/IF, IHC-P, WB
GTX133757 PI3 kinase p110 delta antibody Rb pAb  Hu WB
GTX104639 PI3 kinase p110 gamma antibody [C3], C-term Rb pAb  Hu, Ms, Rat IHC-P, WB  
GTX132466 PI3 kinase p150 antibody Rb pAb  Hu, Ms IHC-P, IP, WB
GTX108953 PI3 kinase p150 antibody [C1C3] Rb pAb  Hu IP, WB  
GTX113094 ERK2 antibody [N2C3] Rb pAb  Hu, Ms, Pig, Rat IHC-P, IP, WB  
GTX101557 mTOR antibody [C3], C-term Rb pAb  Hu, Ms, Rat ICC/IF, IHC-P, IP, WB, ChIP assay  
GTX107562 p70 S6K antibody Rb pAb  Hu, Ms, Rat ICC/IF, IHC-P, WB
GTX132580 mLST8 / GBL antibody Rb pAb  Hu, Ms, Rat IHC-P, WB

 

HIF Degradation

Cat. No. Product Name Host & Clonality Reactivity Applications  
GTX33127 Cullin 2 antibody Rb pAb  Hu WB  
GTX16427 Elongin B antibody Rb pAb  Hu, Ms IP, WB  
GTX65577 TCEB1 antibody Rb pAb  Hu, Ms, Rat IHC-P, WB  
GTX116251 HIF1AN antibody Rb pAb  Hu ICC/IF, IHC-P, WB  
GTX123033 PHD1 antibody Rb pAb  Hu ICC/IF, IHC-P, WB  
GTX132293 PHD2 antibody Rb pAb  Hu, Ms, Rat ICC/IF, IHC-Fr, WB
GTX111217 PHD3 antibody [N1C3] Rb pAb  Hu WB  
GTX116582 PHD4 antibody Rb pAb  Hu IHC-P, WB  
GTX110507 RBX1 antibody Rb pAb  Hu, Ms ICC/IF, WB  
GTX101087 Von Hippel Lindau antibody Rb pAb  Hu, Ms, Rat ICC/IF, IHC-P, IP, WB  

 

HIF-related Transcription Factors

Cat. No. Product Name Host & Clonality Reactivity Applications  
GTX129012 AHR antibody Rb pAb  Hu IHC-P, WB
GTX129013 AHR antibody Rb pAb  Hu, Ms ICC/IF, WB  
GTX22770 AHR antibody [RPT1] Ms mAb Hu, Ms, Pig, Rat, NHuPrm ELISA, ICC/IF, IHC-P, IP, WB, ChIP assay
GTX101249 CBP antibody [C3], C-term Rb pAb  Hu, Ms, Mk ICC/IF, IHC-P, IP, WB, ChIP assay
GTX60477 c-Jun antibody [5B1] Ms mAb Hu, Ms, Mk ELISA, FACS, ICC/IF, IHC-P, WB  
GTX634322 c-Jun (phospho Ser63) antibody [GT653] Ms mAb Hu, Rat ICC/IF, IHC-P, WB
GTX133873 c-Jun (phospho Ser73) antibody Rb pAb  Hu, Ms, Rat ICC/IF, WB  
GTX112846 CREB antibody Rb pAb  Hu, Ms, Rat ICC/IF, IHC-Fr, IHC-P, WB   
GTX130379 CREB (phospho Ser133) antibody Rb pAb  Hu, Ms, Rat WB   
GTX56157 EP300 antibody Rb pAb  Hu, Ms, Chk, Dog, Pig, Rat, Bov IHC, IHC-P, WB
GTX32297 EP300 (phospho Ser1834) antibody Rb pAb  Hu, Ms, Rat WB  
GTX129239 USF2 antibody Rb pAb  Hu, Ms ICC/IF, WB

 

HIF Targets

Cat. No. Product Name Host & Clonality Reactivity Applications  
GTX28452 Angiopoietin 2 antibody Rb pAb  Hu, Ms ELISA, IHC-P, WB
GTX100928 Angiopoietin 2 antibody Rb pAb  Hu, Ms IHC-P, WB
GTX100993 Angiopoietin 4 antibody Rb pAb  Hu, Ms IHC-P, WB  
GTX133555 Beclin 1 antibody Rb pAb  Hu WB   
GTX60413 Beclin 1 antibody [2A4] Ms mAb Hu ELISA, FACS, IHC-P, WB
GTX111876 BNIP3L antibody Rb pAb  Hu, Ms, Rat, Bov ICC/IF, IHC-P, WB
GTX128428 Carbonic Anhydrase IX antibody Rb pAb  Hu, Ms ICC/IF, IHC, IHC-P, WB  
GTX70020 Carbonic Anhydrase IX antibody [GT12] Ms mAb Hu FACS, ICC/IF, IHC, IHC-Fr, IHC-P, IP, WB  
GTX100637 c-Met antibody [C3], C-term Rb pAb  Hu ICC/IF, IP, WB  
GTX631992 c-Met antibody [GT556] Ms mAb Hu IHC-P, IP, WB
GTX103436 c-Myc antibody Rb pAb  Hu, Ms ICC/IF, IHC-P, IP, WB, ChIP assay   
GTX628459 c-Myc antibody [GT168] Ms mAb Hu FACS, IHC-P, IP, WB
GTX104793 Cytochrome b reductase 1 antibody [C2C3], C-term Rb pAb  Hu WB
GTX130889 DMT1 antibody Rb pAb  Ms WB  
GTX116033 Endothelin 1 antibody [C1C3] Rb pAb  Hu ICC/IF, IHC, IHC-P, WB  
GTX22786 Endothelin 1 antibody [TR.ET.48.5] Ms mAb Hu, Ms, Dog, Pig, Rat, Shp FACS, ICC/IF, IHC-Fr, IHC-P, RIA, WB
GTX129843 eNOS antibody Rb pAb  Hu ICC/IF, WB
GTX112834 EPO antibody Rb pAb  Hu, Rat ELISA, IHC-P, WB  
GTX85744 Ferroportin 1 antibody Rb pAb  Hu, Ms ELISA, ICC/IF, IHC-P, WB
GTX112794 Fibronectin antibody [N1N2], N-term Rb pAb  Hu, Ms ELISA, ICC/IF, IHC-P, IP, WB   
GTX15309 GluT1 antibody Rb pAb  Hu IHC-P
GTX113303 HDAC3 antibody Rb pAb  Hu, Ms, Rat ICC/IF, IHC-P, IP, WB, ChIP assay  
GTX101147 Heme Oxygenase 1 antibody Rb pAb  Hu, Ms, Mk, Rat ICC/IF, IHC-P, WB   
GTX111525 Hexokinase II antibody Rb pAb  Hu, Ms, Rat ICC/IF, IHC-P, WB
GTX130246 iNOS antibody Rb pAb  Ms, Rat ICC/IF, IHC-P, WB  
GTX113682 IRE1 alpha antibody [N1N2], N-term Rb pAb  Hu, Chk IP, WB
GTX101416 LDHA antibody Rb pAb  Hu, Ms, Rat ICC/IF, IHC-P, WB
GTX112535 MAT2A antibody [N1C2] Rb pAb  Hu WB
GTX100534 MMP1 antibody Rb pAb  Hu, Ms IHC-P, WB
GTX100665 MMP13 antibody [N3C1], Internal Rb pAb  Hu, Ms, Rat ICC/IF, IHC, IHC-P, WB
GTX132884 MMP14 antibody Rb pAb  Hu, Ms WB  
GTX109378 MMP16 antibody Rb pAb  Hu, Ms, Rat IHC-P, WB
GTX104577 MMP2 antibody Rb pAb  Hu, Ms ICC/IF, IHC-P, IP, WB
GTX100723 MMP3 antibody [N3C1], Internal Rb pAb  Hu ICC/IF, IHC-P, WB
GTX104658 MMP7 antibody [C2C3], C-term Rb pAb  Hu, Ms, Rat, Bov IHC-P, WB
GTX100458 MMP9 antibody [N2C1], Internal Rb pAb  Hu, Bov ICC/IF, IHC-P, WB  
GTX121929 NOX4 antibody [N3C3] Rb pAb  Hu, Ms, Rat ICC/IF, IHC, IHC-P, WB  
GTX101497 Oct4 antibody Rb pAb  Hu, Ms FACS, ICC/IF, IHC-Fr, IHC-P, IP, WB
GTX59636 OLR1 / LOX-1 antibody Rb pAb  Hu, Ms, Rat WB
GTX112898 p21 Cip1 antibody Rb pAb  Hu, Chk ICC/IF, IHC-P, WB   
GTX629543 p21 Cip1 antibody [GT1032] Ms mAb Hu, Ms ICC/IF, IP, WB   
GTX100446 p27 Kip1 antibody Rb pAb  Hu, Ms ICC/IF, IHC-Fr, IHC-P, IP, WB   
GTX54575 PDGF beta antibody Rb pAb  Hu, Ms, Rat IHC-P, WB
GTX105999 Pyruvate dehydrogenase kinase 1 / PDK1 antibody [N1C3] Rb pAb  Hu WB
GTX104763 PD-L1 antibody Rb pAb  Hu ICC/IF, IHC-Fr, IHC-P, WB    
GTX107614 PGK1 antibody Rb pAb  Hu, Ms, Rat, Yeast ELISA, ICC/IF, IHC-P, WB, PLA   
GTX107977 PKM antibody Rb pAb  Hu, Ms, Rat ICC/IF, IHC-P, IP, WB   
GTX116093 SOD2 antibody Rb pAb  Hu, Ms, Rat, Allg, Bird ICC/IF, IHC-P, IP, WB  
GTX111209 STEP / PTPN5 antibody [C1C3] Rb pAb  Hu, Ms IHC-P, WB  
GTX130023 TGF beta 1 antibody Rb pAb  Hu, Ms WB   
GTX21279 TGF beta antibody [TB21] Ms mAb Hu, Ms, Rat, Mink, Rb, Shp, Bov, Mtd ELISA, FACS, IHC, IHC-Fr, IHC-P, Neut, WB
GTX112729 Transferrin antibody [N3C2], Internal Rb pAb  Hu, Rat ICC/IF, IHC-P, WB
GTX29179 CD71 antibody [MEM-75] Ms mAb Hu FACS, ICC/IF, IP
GTX102596 CD71 antibody [N2C1], Internal Rb pAb  Hu, Ms ICC/IF, WB
GTX100621 Twist1 antibody [N1C3] Rb pAb  Hu WB
GTX127310 Twist1/2 antibody Rb pAb  Hu, Ms, Rat IHC-P, WB  
GTX633705 VE-Cadherin antibody [GT1369] Ms mAb Hu ICC/IF, WB
GTX102643 VEGF antibody Rb pAb  Hu, Ms, Rat IHC-P, WB  
GTX129943 VEGF Receptor 2 antibody Rb pAb  Hu WB

 

 

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Pamphlet - Hot Products

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Pamphlet - Antibodies for Cancer Research

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Poster - Hypoxia Regulation

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Poster - Hypoxia Markers

Poster - Hypoxia Markers

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