| Catalog Number | GTX100923 |
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| Product Name | CD143 antibody |
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| Full Name | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 |
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| Synonyms | ACE|ACE1|CD143|DCP|DCP1|MGC26566|MVCD3|angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 |
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| Product Description | Rabbit polyclonal antibody to CD143 (angiotensin I converting enzyme (peptidyl-dipeptidase A) 1) |
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| Background | This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes - the somatic form and the testicular form that are equally active. Multiple additional alternatively spliced variants have been identified but their full length nature has not been determined. [provided by RefSeq] |
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| Host | Rabbit |
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| Clonality | Polyclonal |
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| Immunogen | Recombinant protein fragment contain a sequence corresponding to a region within amino acids 401 and 731 of Human CD143 |
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| Antigen Species | Human |
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| Species Cross Reactivity | Human - Not yet tested in other species |
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| Predicted Cross Reactivity Species | rabbit(87%), pig(83%) |
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| Tested Applications | Western blot. The usefulness of this product in other applications has not been determined. |
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| Application Note | Suggested starting dilutions are as follows. WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user. |
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| Positive Controls | 293T | A431 | H1299 |
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| Target | CD143 |
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| Predicted Target Size(KDa) | 83 |
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| Cellular Localization | Angiotensin-converting enzyme | soluble form: Secreted | Cell membrane |
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| Form Supplied | Liquid |
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| Concentration | 0.58 mg/ml |
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| Purification | Purified by antigen-affinity chromatography. |
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| Storage Buffer | 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
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| Storage Instruction | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
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| Notes | For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. |
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