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CD3 antibody [17A2]

Cat. No. GTX01458

Reference 261

Host

 Rat

Clonality

 Monoclonal

Clone Name

 17A2

Isotype

 IgG2b

Application

 IHC-Fr, FACS, IP, Depletion

Reactivity

 Mouse
Package
100 μg ($119)
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PRODUCT

Summary

The 17A2 antibody reacts with the mouse CD3 complex, comprised of CD3 epsilon, CD3 gamma and CD3 delta. These integral membrane protein chains assemble with additional chains of the T cell receptor (TCR), as well as CD3 zeta chain, to form the T cell receptor – CD3 complex. Together with co-receptors CD4 or CD8, the complex serves to recognize antigens bound to MHC molecules on antigen-presenting cells. Such interactions promote T cell receptor signaling (T cell activation) and can result in a number of cellular responses including proliferation, differentiation, production of cytokines or activation-induced cell death. CD3 is differentially expressed during thymocyte-to-T cell development and on all mature T cells. The 17A2 antibody is a widely used phenotypic marker for mouse T cells. In addition, as the CD3e chain within the TCR complex contains intracellular signaling domains, binding of 17A2 antibody to CD3 can induce cell activation (use format suitable for functional assays).

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-Fr Assay dependent
FACS Assay dependent
IP Assay dependent
Depletion Assay dependent
Not tested in other applications.

PROPERTIES

Form

Liquid

Buffer

10mM NaH₂PO₄, 150mM NaCl

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

Purification

Purified by affinity chromatography
From tissue culture supernatant

Purity

> 90% (determined by SDS-PAGE)

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD3 antigen, delta polypeptide , CD3 antigen, epsilon polypeptide , CD3 antigen, gamma polypeptide , CD247 antigen , T3d , AI504783 , CD3 , CD3epsilon , T3e , Ctg-3 , Ctg3 , T3g , 4930549J05Rik , A430104F18Rik , AW552088 , Cd3 , Cd3-eta , Cd3-zeta , Cd3h , Cd3z , Cd3zeta , T3z , Tcrk , Tcrz

Cellular Localization

Cell membrane , Membrane; Single-pass type I membrane protein

Database

Research Area

REFERENCE

Application Reference

Yuan J et al. Protein Cell 2021; 12 (4) : 240-260 Potentiating CD8+ T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling.
Application : FACS
Heffer AM et al. PLoS One 2020; 15 (12) : e0243626 Salinomycin inhibits proliferative vitreoretinopathy formation in a mouse model.

Clone Reference

Shah S et al. Pathogens 2020; 9 (8) MCMV Dissemination from Latently-Infected Allografts Following Transplantation into Pre-Tolerized Recipients.
Cassidy BR et al. J Neuroinflammation 2020; 17 (1):259 Neuroinvasive Listeria monocytogenes infection triggers accumulation of brain CD8+ tissue-resident memory T cells in a miR-155-dependent fashion.
Dhayade S et al. Nutrients 2020; 12 (8) Impact of Formate Supplementation on Body Weight and Plasma Amino Acids.
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REVIEW

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Application Reference
Yuan J et al. Protein Cell 2021; 12 (4):240-260 Potentiating CD8+ T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling.
Application : FACS
Heffer AM et al. PLoS One 2020; 15 (12):e0243626 Salinomycin inhibits proliferative vitreoretinopathy formation in a mouse model.
Clone Reference
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1989; Production and characterization of a rat monoclonal antibody against the murine CD3 molecular complex.
Application : IHC-Fr, FACS, IP, Depletion
Reactivity : Mouse
SDS
Sodium Azide.pdf
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