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NFkB p65 antibody

KO/KD Orthogonal Overexpression IP/MS
Anti-NFkB p65 antibody used in Western Blot (WB). GTX102090
Anti-NFkB p65 antibody used in Western Blot (WB). GTX102090
Anti-NFkB p65 antibody used in IHC (Paraffin sections) (IHC-P). GTX102090
Anti-NFkB p65 antibody used in IHC (Paraffin sections) (IHC-P). GTX102090
Anti-NFkB p65 antibody used in IHC (Paraffin sections) (IHC-P). GTX102090
Anti-NFkB p65 antibody used in Western Blot (WB). GTX102090
Anti-NFkB p65 antibody used in IHC (Paraffin sections) (IHC-P). GTX102090
Anti-NFkB p65 antibody used in IHC (Paraffin sections) (IHC-P). GTX102090
Anti-NFkB p65 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX102090
Anti-NFkB p65 antibody used in Western Blot (WB). GTX102090
Anti-NFkB p65 antibody used in IHC (Frozen sections) (IHC-Fr). GTX102090
Anti-NFkB p65 antibody used in Western Blot (WB). GTX102090
Anti-NFkB p65 antibody used in IHC (Paraffin sections) (IHC-P). GTX102090
Anti-NFkB p65 antibody used in Western Blot (WB). GTX102090
Anti-NFkB p65 antibody used in Western Blot (WB). GTX102090
Anti-NFkB p65 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX102090
Anti-NFkB p65 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX102090

Cat. No. GTX102090

Reference 74
4

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-P, IHC-Fr, IP, ChIP assay

Reactivity

 Human, Mouse, Rat
Package
100 μl ($399),
25 μl ($169)
See all NFkB p65 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500-1:10000
ICC/IF 1:100-1:1000
IHC-P 1:100-1:1000
IHC-Fr Assay dependent
IP Assay dependent
ChIP assay Assay dependent
Not tested in other applications.

Calculated MW

60 kDa. ( Note )

Positive Control

human NFkB p65-transfected 293T

Product Note

IP/MS validation was supported by references (PMID:30377380)

Predict Reactivity

Bovine, Pig, Chimpanzee(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS, 1% BSA, 20% Glycerol

Preservative

0.025% ProClin 300

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.49 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant protein encompassing a sequence within the center region of human NFkB p65. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

RRID

AB_10630493

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

RELA proto-oncogene, NF-kB subunit , CMCU , NFKB3 , p65

Cellular Localization

Nucleus , Cytoplasm

Background

NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM]

Database

Research Area

DATA IMAGES

Anti-NFkB p65 antibody used in Western Blot (WB). GTX102090

GTX102090 WB Image

KO/KD

Wild-type (WT) and RELA knockout (KO) HeLa cell extracts (30 μg) were separated by 7.5% SDS-PAGE, and the membrane was blotted with NFkB p65 antibody (GTX102090) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-NFkB p65 antibody used in Western Blot (WB). GTX102090

GTX102090 WB Image

Overexpression

Non-transfected (–) and transfected (+) 293T whole cell extracts (30 μg) were separated by 7.5% SDS-PAGE, and the membrane was blotted with NFkB p65 antibody (GTX102090) diluted at 1:5000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-NFkB p65 antibody used in IHC (Paraffin sections) (IHC-P). GTX102090

GTX102090 IHC-P Image

NFkB p65 antibody detects NFkB p65 protein at cytoplasm by immunohistochemical analysis.
Sample: Paraffin-embedded mouse heart.
NFkB p65 stained by NFkB p65 antibody (GTX102090) diluted at 1:500.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-NFkB p65 antibody used in IHC (Paraffin sections) (IHC-P). GTX102090

GTX102090 IHC-P Image

NFkB p65 antibody detects NFkB p65 protein at cytoplasm by immunohistochemical analysis.
Sample: Paraffin-embedded mouse muscle.
NFkB p65 stained by NFkB p65 antibody (GTX102090) diluted at 1:500.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-NFkB p65 antibody used in IHC (Paraffin sections) (IHC-P). GTX102090

GTX102090 IHC-P Image

NFkB p65 antibody detects NFkB p65 protein at cytoplasm and nucleus by immunohistochemical analysis.
Sample: Paraffin-embedded mouse kidney.
NFkB p65 stained by NFkB p65 antibody (GTX102090) diluted at 1:500.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-NFkB p65 antibody used in Western Blot (WB). GTX102090

GTX102090 WB Image

Various whole cell extracts (30 μg) were separated by 7.5% SDS-PAGE, and the membrane was blotted with NFkB p65 antibody (GTX102090) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-NFkB p65 antibody used in IHC (Paraffin sections) (IHC-P). GTX102090

GTX102090 IHC-P Image

NFkB p65 antibody detects NFkB p65 protein at cytoplasm and nucleus by immunohistochemical analysis.
Sample: Paraffin-embedded mouse kidney.
NFkB p65 stained by NFkB p65 antibody (GTX102090) diluted at 1:165.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-NFkB p65 antibody used in IHC (Paraffin sections) (IHC-P). GTX102090

GTX102090 IHC-P Image

NFkB p65 antibody detects NFkB p65 protein at cytosol and nucleus on human breast carcinoma by immunohistochemical analysis.
Sample: Paraffin-embedded human breast carcinoma.
NFkB p65 antibody (GTX102090) dilution: 1:500.

Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min

Anti-NFkB p65 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX102090

GTX102090 ICC/IF Image

Confocal immunofluorescence analysis (Olympus FV10i) of paraformaldehyde-fixed U2OS, using NFkB p65(GTX102090) antibody (Green) at 1:500 dilution. Alpha-tubulin filaments were labeled with GTX11304 (Red) at 1:2000.

Anti-NFkB p65 antibody used in Western Blot (WB). GTX102090

GTX102090 WB Image

Various whole cell extracts (30 μg) were separated by 7.5% SDS-PAGE, and the membrane was blotted with NFkB p65 antibody (GTX102090) diluted at 1:1000.

Anti-NFkB p65 antibody used in IHC (Frozen sections) (IHC-Fr). GTX102090

GTX102090 IHC-Fr Image

Orthogonal

The data was published in the journal PLoS One in 2018. PMID: 29617457

Anti-NFkB p65 antibody used in Western Blot (WB). GTX102090

GTX102090 WB Image

Orthogonal

The data was published in the journal Int J Mol Sci in 2018. PMID: 30314265

Anti-NFkB p65 antibody used in IHC (Paraffin sections) (IHC-P). GTX102090

GTX102090 IHC-P Image

Orthogonal

The data was published in the journal J Neuroinflammation in 2017. PMID: 28865458

Anti-NFkB p65 antibody used in Western Blot (WB). GTX102090

GTX102090 WB Image

The data was published in the 2022 in Front Pharmacol. PMID: 35308231

Anti-NFkB p65 antibody used in Western Blot (WB). GTX102090

GTX102090 WB Image

The data was published in the journal Int J Mol Sci in 2017. PMID: 29084133

Anti-NFkB p65 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX102090

GTX102090 ICC/IF Image

The data was published in the journal PLoS One in 2017. PMID: 28301550

Anti-NFkB p65 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX102090

GTX102090 ICC/IF Image

The data was published in the journal Int J Mol Sci in 2017. PMID: 29084133

REFERENCE

Application Reference

Li LH et al. Int J Mol Sci 2024; 25 (16) Inhibiting CD44-ICD Attenuates LPS-Induced Initiation of Hepatic Inflammation in Septic Mice.
Vald?s-Fuentes M et al. Int J Mol Sci 2024; 25 (10) Accumulation of Alpha-Synuclein and Increase in the Inflammatory Response in the substantia nigra, Jejunum, and Colon in a Model of O(3) Pollution in Rats.
Rivas-Arancibia S et al. Antioxidants (Basel) 2024; 13 (5) Changes in SOD and NF-κB Levels in Substantia Nigra and the Intestine through Oxidative Stress Effects in a Wistar Rat Model of Ozone Pollution.
M Vald?s-Fuentes et al. Preprints 2024; Accumulation of Alpha-Synuclein and Increase in the Inflammatory Response in the Substantia Nigra, Jejunum, and Colon, in a Model of O3 Pollution in Rats
Application : WB
Li D et al. Heliyon 2024; 10 (5) : e27644 DL-3-n-butylphthalide attenuates doxorubicin-induced acute cardiotoxicity via Nrf2/HO-1 signaling pathway.
Show More +
Submit a Reference

REVIEW

NFkB p65 antibody Cat. No. GTX102090

Rating
( Average 4.3 based on 4 users reviews)
Application
Western Blot(WB)
( Average 4.3 based on 4 users reviews)
Anti-NFkB p65 antibody used in Western Blot (WB). GTX102090
Date : Anonymous submitted on 01-May-2024
Score :
Application Tested : WB
Sample Species : Hu
Sample : THP-1 cells
Amount used : 25μg
Blocking : 5% non-fat milk in TBST, 22°C, 1Hr
Primary Antibody : 1:4000, 4°C, 16Hr
Anti-NFkB p65 antibody used in Western Blot (WB). GTX102090
Date : Anonymous submitted on 31-May-2021
Score :
Application Tested : WB
Sample Species : Hu
Sample : SW1353 cells
Amount used : 20 μg
Blocking : 5% skim milk, 25°C, 1Hr
Primary Antibody : 1:2000, 4°C, 16Hr
Figure Note : NFkB p65 nuclear translocation induced by IL-1β(10ng/ml, 24h).
Anti-NFkB p65 antibody used in Western Blot (WB). GTX102090
Date : Anonymous submitted on 18-Jul-2017
Score :
Application Tested : WB
Sample Species : Ms
Sample : mpkCCD cells
Amount used : 50 μg
Blocking : 0.1%BSA in TBST, 25°C, 1Hr
Primary Antibody : 1:1000, 4°C, 16Hr
Anti-NFkB p65 antibody used in Western Blot (WB). GTX102090
Date : Anonymous submitted on 30-Aug-2016
Score :
Application Tested : WB
Sample Species : Ms
Sample : Neuro-2a cells
Amount used : 25μg
Blocking : 5% milk in 0.1% PBST, 25°C, 1Hr
Primary Antibody : 1:2000, 4°C, 16Hr
Submit a Review
Application Reference
Li LH et al. Int J Mol Sci 2024; 25 (16) Inhibiting CD44-ICD Attenuates LPS-Induced Initiation of Hepatic Inflammation in Septic Mice.
Vald?s-Fuentes M et al. Int J Mol Sci 2024; 25 (10) Accumulation of Alpha-Synuclein and Increase in the Inflammatory Response in the substantia nigra, Jejunum, and Colon in a Model of O(3) Pollution in Rats.
Rivas-Arancibia S et al. Antioxidants (Basel) 2024; 13 (5) Changes in SOD and NF-κB Levels in Substantia Nigra and the Intestine through Oxidative Stress Effects in a Wistar Rat Model of Ozone Pollution.
M Vald?s-Fuentes et al. Preprints 2024; Accumulation of Alpha-Synuclein and Increase in the Inflammatory Response in the Substantia Nigra, Jejunum, and Colon, in a Model of O3 Pollution in Rats
Application : WB
Li D et al. Heliyon 2024; 10 (5):e27644 DL-3-n-butylphthalide attenuates doxorubicin-induced acute cardiotoxicity via Nrf2/HO-1 signaling pathway.
Kano T et al. Exp Biol Med (Maywood) 2023; 248 (20):1895-1904 The infrapatellar fat pad contributes to spontaneous healing after complete anterior cruciate ligament injury.
Hee SW et al. iScience 2023; 26 (10):107997 15-keto-PGE(2) alleviates nonalcoholic steatohepatitis through its covalent modification of NF-κB factors.
AS Arellano Buendia et al. PeerJ 2023; Antioxidant and anti-inflammatory effects of allicin in the kidney of an experimental model of metabolic syndrome
Huang SC et al. J Tradit Complement Med 2023; 13 (5):511-520 Gastroprotective effects of Machilus zuihoensis Hayata bark against acidic ethanol-induced gastric ulcer in mice.
Y Hasegawa et al. Biochem Biophys Rep 2023; 35:101538 DNA-dependent protein kinase catalytic subunit binds to the transactivation domain 1 of NF-κB p65
Application : WB, IP
Teramoto H et al. Cells 2023; 12 (14) Calcineurin B1 Deficiency Reduces Proliferation, Increases Apoptosis, and Alters Secretion in Enteric Glial Cells of Mouse Small Intestine in Culture.
Yang JX et al. Neuroreport 2023; 34 (12):638-648 Electroacupuncture relieves chronic pain by promoting microglia M2 polarization in lumbar disc herniation rats.
GASPARELLO et al. Int J Mol Med 2023; 52:76 Effects of Sulforaphane on SARS?CoV?2 infection and NF?κB dependent expression of genes involved in the COVID?19 ‘cytokine storm’
Application : WB
Alian HA et al. Biol Trace Elem Res 2023; 201 (8):4062-4078 Nano Zinc Oxide Improves Performance, IGF-I mRNA Expression, Meat Quality, and Humeral Immune Response and Alleviates Oxidative Stress and NF-κB Immunohistochemistry of Broiler Chickens.
Shih-Cheng Huang et al. J. Tradit. Complement. Med. 2023; Gastroprotective effects of Machilus zuihoensis Hayata against acidic ethanol-induced gastric ulcer in mice
Application : WB
Reactivity : Mouse
Liu PI et al. Aging (Albany NY) 2023; 15 (5):1652-1667 ANGPTL2 promotes VEGF-A synthesis in human lung cancer and facilitates lymphangiogenesis.
Application : WB
Reactivity : Human
Li CJ et al. J Hepatocell Carcinoma 2023; 10:123-138
Application : WB
Reactivity : Human
Zhang W et al. Oxid Med Cell Longev 2023; 2023:9966355 Tubeimoside I Ameliorates Doxorubicin-Induced Cardiotoxicity by Upregulating SIRT3.
Application : WB
Reactivity : Mouse, Rat
Cardile A et al. Int J Mol Sci 2023; 24 (2) Hyperforin Elicits Cytostatic/Cytotoxic Activity in Human Melanoma Cell Lines, Inhibiting Pro-Survival NF-κB, STAT3, AP1 Transcription Factors and the Expression of Functional Proteins Involved in Mitochondrial and Cytosolic Metabolism.
Li Y et al. Exp Ther Med 2022; 24 (3):567 Interleukin 32 participates in cardiomyocyte-induced oxidative stress, inflammation and apoptosis during hypoxia/reoxygenation via the NOD2/NOX2/MAPK signaling pathway.
Application : WB
Reactivity : Human
Ping SH et al. Iran J Basic Med Sci 2022; 25 (10):1228-1233 Protective effects of equol on the cartilage and subchondral bone in ovariectomized rats with osteoarthritis.
Yu Fu et al. Evid Based Complement Alternat Med 2022; 2022:9131178 Biejiajian Pill Ameliorates Diabetes-Associated Atherosclerosis through Inhibition of the NLRP3 Inflammasome.
Application : WB
Reactivity : Mouse
Manuela Leo et al. Antioxidants (Basel) 2022; 11 (4) Polyphenols Extracts from Oil Production Waste Products (OPWPs) Reduce Cell Viability and Exert Anti-Inflammatory Activity via PPARγ Induction in Colorectal Cancer Cells.
Application : WB
Reactivity : Human
Vichuda Charoensaensuk et al. Antioxidants (Basel) 2022; 11 (4) 2,3,5,4'-Tetrahydroxystilbene-2-O-β-glucoside Attenuates Reactive Oxygen Species-Dependent Inflammation and Apoptosis in Porphyromonas gingivalis-Infected Brain Endothelial Cells.
Application : WB
Xue Zhang et al. Front Pharmacol 2022; 13:827128 A Polysaccharide From Eupolyphaga sinensis Walker With Anti-HBV Activities In Vitro and In Vivo.
Application : WB
Reactivity : Human
Li Y et al. Bioengineered 2022; 13 (1):800-809 Sitagliptin ameliorates hypoxia-induced damages in endometrial stromal cells: an implication in endometriosis.
Application : WB
Reactivity : Human
Yan T et al. FASEB J 2021; 35 (11):e21968 St. John's Wort alleviates dextran sodium sulfate-induced colitis through pregnane X receptor-dependent NFκB antagonism.
Charoensaensuk V et al. Cells 2021; 10 (11) Porphyromonas gingivalis Induces Proinflammatory Cytokine Expression Leading to Apoptotic Death through the Oxidative Stress/NF-κB Pathway in Brain Endothelial Cells.
Application : WB
Reactivity : Mouse
Lee KT et al. Aging (Albany NY) 2021; 13 (18):22490-22501 Nesfatin-1 facilitates IL-1β production in osteoarthritis synovial fibroblasts by suppressing miR-204-5p synthesis through the AP-1 and NF-κB pathways.
Application : WB
Reactivity : Human
Su C.H. et al. Journal of Functional Foods 2021; 86 Betulin suppresses TNF-α and IL-1β production in osteoarthritis synovial fibroblasts by inhibiting the MEK/ERK/NF-κB pathway.
Application : WB
Reactivity : Human
Hattori H et al. Mol Med Rep 2021; 24 (3) Senescent RAW264.7 cells exhibit increased production of nitric oxide and release inducible nitric oxide synthase in exosomes.
Zhang J et al. Mediators Inflamm 2021; 2021:6611085 Anti-Interleukin-16-Neutralizing Antibody Attenuates Cardiac Inflammation and Protects against Cardiac Injury in Doxorubicin-Treated Mice.
Application : WB
Reactivity : Mouse
Lin ZC et al. Theranostics 2021; 11 (10):4567-4584 Monovalent antibody-conjugated lipid-polymer nanohybrids for active targeting to desmoglein 3 of keratinocytes to attenuate psoriasiform inflammation.
Application : ICC/IF
Reactivity : Human
Biswas S et al. Asian Pac J Cancer Prev 2021; 22 (3):957-970 Curcumin Rescues Doxorubicin Responsiveness via Regulating Aurora a Signaling Network in Breast Cancer Cells.
Application : WB
Reactivity : Human
Wang Y et al. Aging (Albany NY) 2020; 12 (20):20184-20197 Interleukin-6 knockout reverses macrophage differentiation imbalance and alleviates cardiac dysfunction in aging mice.
Chang YX et al. Cancers (Basel) 2020; 12 (12) Chaperonin-Containing TCP-1 Promotes Cancer Chemoresistance and Metastasis through the AKT-GSK3β-β-Catenin and XIAP-Survivin Pathways.
Application : WB
Reactivity : Human
Chan HC et al. Biomedicines 2020; 8 (12) An Increased Plasma Level of ApoCIII-Rich Electronegative High-Density Lipoprotein May Contribute to Cognitive Impairment in Alzheimer's Disease.
Application : WB
Reactivity : Mouse
Zhu S et al. J Agric Food Chem 2020; 68 (42):11726-11734 Collagen Hydrolysate Corrects Anemia in Chronic Kidney Disease via Anti-Inflammatory Renoprotection and HIF-2α-Dependent Erythropoietin and Hepcidin Regulation.
Application : WB
Reactivity : Mouse
Chung PC et al. Evid Based Complement Alternat Med 2020; 2020:8373715 Role of Chrysophanol in Epithelial-Mesenchymal Transition in Oral Cancer Cell Lines via a Wnt-3-Dependent Pathway.
Application : WB
Reactivity : Human
Chang JW et al. Cereb Cortex 2020; 30 (8):4597-4606 Ultrasound Stimulation Suppresses LPS-Induced Proinflammatory Responses by Regulating NF-κB and CREB Activation in Microglial Cells.
Application : WB
Reactivity : Rat
Chao CC et al. Cancers (Basel) 2020; 12 (2) CXCL1/CXCR2 Paracrine Axis Contributes to Lung Metastasis in Osteosarcoma.
Application : IP
Reactivity : Human
Chen CY et al. Front Oncol 2020; 10:216 Hydroxygenkwanin Inhibits Class I HDAC Expression and Synergistically Enhances the Antitumor Activity of Sorafenib in Liver Cancer Cells.
Application : WB
Reactivity : Human
Gandhi KA et al. Free Radic Biol Med 2019; 145:8-19 Oral administration of 3,3'-diselenodipropionic acid prevents thoracic radiation induced pneumonitis in mice by suppressing NF-kB/IL-17/G-CSF/neutrophil axis.
Application : IHC-P
Reactivity : Mouse
Wang Z et al. Int Immunopharmacol 2019; 76:105873 Butylphthalide ameliorates airway inflammation and mucus hypersecretion via NF-庥B in a murine asthma model.
Li J et al. J Allergy Clin Immunol 2019; Hypomethylation of the IL8 promoter in nasal epithelial cells of patients with chronic rhinosinusitis with nasal polyps.
Li HY et al. J Agric Food Chem 2019; 67 (7):1889-1901 Melatonin Inhibits in Vitro Smooth Muscle Cell Inflammation and Proliferation and Atherosclerosis in Apolipoprotein E-Deficient Mice.
Application : WB
Reactivity : Rat
Li R et al. Int J Biol Macromol 2019; 123:1035-1043 NF-κB signaling and integrin-β1 inhibition attenuates osteosarcoma metastasis via increased cell apoptosis.
Application : WB, IHC-P
Reactivity : Human
Leigh J et al. Can Urol Assoc J 2018; (Epub) Endogenous H2S production deficiencies lead to impaired renal erythropoietin production.
Application : WB
Reactivity : Mouse
Sikorski K et al. Nat Methods 2018; 15 (11):909-912 A high-throughput pipeline for validation of antibodies.
Application : IP
Reactivity : Human
Arellano Buendia AS et al. Int J Mol Sci 2018; 19 (10) Immunomodulatory Effects of the Nutraceutical Garlic Derivative Allicin in the Progression of Diabetic Nephropathy.
Application : WB
Reactivity : Rat
Chen ST et al. Oncogene 2018; (Epub) Silencing of MUC20 suppresses the malignant character of pancreatic ductal adenocarcinoma cells through inhibition of the HGF/MET pathway.
Application : WB
Reactivity : Human
Krga I et al. Free Radic Biol Med 2018; 124:364-379 Anthocyanins and their gut metabolites attenuate monocyte adhesion and transendothelial migration through nutrigenomic mechanisms regulating endothelial cell permeability.
Application : WB
Reactivity : Human
Gerzanich V et al. PLoS One 2018; 13 (4):e0195526 SUR1-TRPM4 channel activation and phasic secretion of MMP-9 induced by tPA in brain endothelial cells.
Application : IHC-Fr
Reactivity : Rat
Wang Y et al. Neural Plasticity 2018; 2018:7254016 TLR4-NF-κB Signal Involved in Depressive-Like Behaviors and Cytokine Expression of Frontal Cortex and Hippocampus in Stressed C57BL/6 and ob/ob Mice.
Application : IHC-P
Reactivity : Mouse
Wang Y et al. Neural Plasticity 2018; (Epub) TLR4-NF-κB Signal Involved in Depressive-like Behaviors and Cytokines Expression of Frontal Cortex and Hippocampus in Stressed C57BL/6 and ob/ob Mice.
Application : IHC-P
Reactivity : Mouse
Ricci C et al. Sci Rep 2018; 8 (1):2267 PCSK9 induces a pro-inflammatory response in macrophages.
Application : ICC/IF
Reactivity : Human
Tsai CH et al. Sci Rep 2017; 7 (1):15624 A standardized herbal extract mitigates tumor inflammation and augments chemotherapy effect of * in prostate cancer.
Application : IHC-P
Reactivity : Human
Chamard-Jovenin C et al. Front Endocrinol (Lausanne) 2017; 8:272 Low-Dose Alkylphenol Exposure Promotes Mammary Epithelium Alterations and Transgenerational Developmental Defects, But Does Not Enhance Tumorigenic Behavior of Breast Cancer Cells.
Application : ICC/IF
Reactivity : Human
Menicacci B et al. Int J Mol Sci 2017; 18 (11) Modulation of the Senescence-Associated Inflammatory Phenotype in Human Fibroblasts by Olive Phenols.
Application : WB
Reactivity : Human
Mahajan SD et al. Immunol Invest 2017; 46 (8):816-832 Immunomodulatory Role of Complement Proteins in the Neuropathology Associated with Opiate Abuse and HIV-1 Co-Morbidity.
Application : IHC-Fr
Reactivity : Human
Sharma RK et al. Immunol Invest 2017; 46 (8):833-846 Immunomodulatory activities of curcumin-stabilized silver nanoparticles: Efficacy as an antiretroviral therapeutic.
Application : ICC/IF
Reactivity : Human
Wyss JC et al. Am J Physiol Renal Physiol 2017;:ajprenal.00414.2016 Targeted gamma-secretase inhibition of Notch signaling activation in acute renal injury.
Application : IHC-P
Reactivity : Mouse
Andreucci E et al. J Mol Med (Berl) 2017; (Epub) Carbonic anhydrase IX inhibition affects viability of cancer cells adapted to extracellular acidosis.
Application : ICC/IF
Reactivity : Human
Gerzanich V. et al. J Neuroinflammation 2017; 14:177 Salutary effects of glibenclamide during the chronic phase of murine experimental autoimmune encephalomyelitis.
Application : IHC-P
Reactivity : Mouse
Kuo CY et al. Cancer Res 2017; (Epub) VHL inactivation in precancerous kidney cells induces an inflammatory response via ER stress-activated IRE1α signaling.
Application : WB
Reactivity : Human
Huang YC et al. Toxicol Appl Pharmacol 2017; 329:128-139 galangin ameliorates *-induced nephrotoxicity by attenuating oxidative stress, inflammation and cell death in mice through inhibition of erk and nf-kappab signaling.
Application : WB
Reactivity : Mouse
Liu MC et al. PLoS One 2017; 12 (5):e0178152 Inhibition of chronic prostate inflammation by hyaluronic acid through an immortalized human prostate stromal cell line model.
Application : WB
Reactivity : Human
Thiebaut C et al. PLoS One 2017; 12 (3):e0173931 Mammary epithelial cell phenotype disruption in vitro and in vivo through ERalpha36 overexpression.
Application : WB, ICC/IF
Reactivity : Human
Leu JS et al. Am J Respir Crit Care Med 2016; SP110b Controls Host Immunity and Susceptibility to Tuberculosis.
Application : WB
Reactivity : Human
Chen WH et al. Am J Sports Med 2016; (Epub) Functional Recovery in Osteoarthritic Chondrocytes Through Hyaluronic Acid and Platelet-Rich Plasma-Inhibited Infrapatellar Fat Pad Adipocytes.
Application : WB
Reactivity : Human
Raninga PV et al. Cell Cycle 2016; ([Epub]) trxr1 inhibition overcomes both hypoxia-induced and acquired * resistance in multiple myeloma through nf-kβ inhibition.
Application : WB
Reactivity : Human
F?ri I et al. PLoS One 2015; 10 (7):e0131699 Cell Free DNA of Tumor Origin Induces a 'Metastatic' Expression Profile in HT-29 Cancer Cell Line.
Application : ICC/IF
Reactivity : Human
Heng-Hsiung Wu et al. J Exp Med 2015; 212 (3):333-49 Targeting IL-17B-IL-17RB signaling with an anti-IL-17RB antibody blocks pancreatic cancer metastasis by silencing multiple chemokines.
Application : WB, ChIP assay
Reactivity : Human
Wang S et al. PLoS Genet 2013; 9 (9):e1003750 An enhancer element harboring variants associated with systemic lupus erythematosus engages the TNFAIP3 promoter to influence A20 expression.
Application : WB
Reactivity : Human
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