PRODUCT
Summary
Anaplastic large cell lymphoma (ALCL) is usually composed of large pleomorphic cells, which express CD30 antigen and the epithelial membrane antigen (EMA). These tumor cells tend to occur in younger patients and may be associated with cutaneous and extranodal involvement. Large cell lymphoma account for approximately 25% of all non-Hodgkin lymphomas in children and young adults.
APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:25-1:140 |
Not tested in other applications.
Calculated MW
Positive Control
Anaplastic Lymphoma
PROPERTIES
Form
Liquid
Buffer
Tissue culture supernatant
Preservative
0.09% sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.
Immunogen
Prokaryotic recombinant protein corresponding to a region which spans the tyrosine kinase catalytic domain and part of the C-terminus of NPM-ALK transcript (419-520 aa).
Purification
Unpurified
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
ALK receptor tyrosine kinase , CD246 , NBLST3
Cellular Localization
Cell membrane
Background
This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]
Database
Research Area
DATA IMAGES
![Anti-ALK antibody [5A4] used in IHC (Paraffin sections) (IHC-P). GTX73978](/templates/default/js/lightbox/images/loading.gif "Anti-ALK antibody [5A4] used in IHC (Paraffin sections) (IHC-P). GTX73978")
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GTX73978 IHC-P Image
IHC-P analysis of human anaplastic lymphoma tissue using GTX73978 ALK antibody [5A4].
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REFERENCE
There are currently no references for ALK antibody [5A4] (GTX73978). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for ALK antibody [5A4] (GTX73978). Be the first to share your experience with this product.
![Anti-ALK antibody [5A4] used in IHC (Paraffin sections) (IHC-P). GTX73978](/upload/website/prouct_img/small/GTX73978/GTX73978_20230725_IHC-P_23072502_175.webp "Anti-ALK antibody [5A4] used in IHC (Paraffin sections) (IHC-P). GTX73978")
![Anti-ALK antibody [5A4] used in IHC (Paraffin sections) (IHC-P). GTX73978](/upload/website/prouct_img/normal/GTX73978/GTX73978_20230725_IHC-P_23072502_175.webp "Anti-ALK antibody [5A4] used in IHC (Paraffin sections) (IHC-P). GTX73978")