APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:100-1:200 |
Not tested in other applications.
PROPERTIES
Form
Liquid
Buffer
PBS, 2% BSA
Preservative
0.025% ProClin 300
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
batch dependent
Antigen Species
Human
Immunogen
Recombinant fragmemt of human CBP
Purification
Affinity purified by Protein A.
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
CREB binding protein,CBP,KAT3A,MKHK1,RSTS,RSTS1
Cellular Localization
Cytoplasm,Nucleus
Background
This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]
Database
Research Area
DATA IMAGES
![Anti-CBP antibody [HMV319] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639943](/templates/default/js/lightbox/images/loading.gif "Anti-CBP antibody [HMV319] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639943")
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GTX639943 IHC-P Image
IHC-P analysis of human stomach gastric adenocarcinoma tissue using GTX639943 CBP antibody [HMV319] HistoMAX™.
Gastric adenocarcinoma (intestinal type) showing strong CBP staining of tumor cells.
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GTX639943 IHC-P Image
IHC-P analysis of human soft tissue using GTX639943 CBP antibody [HMV319] HistoMAX™
Malignant peripheral nerve sheath tumor (MPNST) with strong CBP positivity of tumor cells.
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GTX639943 IHC-P Image
IHC-P analysis of human uterus endometrium (proliferation) tissue using GTX639943 CBP antibody [HMV319] HistoMAX™.
Uterus, endometrium (proliferation).
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REFERENCE
There are currently no references for CBP antibody [HMV319] HistoMAX™ (GTX639943). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for CBP antibody [HMV319] HistoMAX™ (GTX639943). Be the first to share your experience with this product.
![Anti-CBP antibody [HMV319] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639943](/upload/website/prouct_img/small/GTX639943/GTX639943_20240408_IHC-P_2_24040801_722.webp "Anti-CBP antibody [HMV319] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639943")
![Anti-CBP antibody [HMV319] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639943](/upload/website/prouct_img/small/GTX639943/GTX639943_20240408_IHC-P_1_24040801_553.webp "Anti-CBP antibody [HMV319] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639943")
![Anti-CBP antibody [HMV319] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639943](/upload/website/prouct_img/small/GTX639943/GTX639943_20240408_IHC-P_24040801_477.webp "Anti-CBP antibody [HMV319] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639943")
![Anti-CBP antibody [HMV319] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639943](/upload/website/prouct_img/normal/GTX639943/GTX639943_20240408_IHC-P_2_24040801_722.webp "Anti-CBP antibody [HMV319] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639943")
![Anti-CBP antibody [HMV319] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639943](/upload/website/prouct_img/normal/GTX639943/GTX639943_20240408_IHC-P_1_24040801_553.webp "Anti-CBP antibody [HMV319] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639943")
![Anti-CBP antibody [HMV319] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639943](/upload/website/prouct_img/normal/GTX639943/GTX639943_20240408_IHC-P_24040801_477.webp "Anti-CBP antibody [HMV319] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639943")