CD11b antibody [M1/70]

Cat. No. GTX00608
Cat. No.  GTX00608
  • Host
    Rat
  • Clonality
    Monoclonal
  • Clone Name
    M1/70
  • Isotype
    IgG2b
  • Applications
    ICC/IF IHC-P IHC-Fr FACS IP Depletion Neutralizing/Inhibition
  • Reactivity
    Human, Mouse, Rabbit, Baboon, Chimpanzee, Cynomolgus monkey, Rhesus Monkey
Summary
The M1/70 antibody reacts with human and mouse CD11b, also known as integrin αalpha M. This 165-170 kDa cell surface glycoprotein is part of a family of integrin αreceptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrin αs are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin αreceptors consist of distinct combinations of integrin αchains which are differentially expressed. integrin αalpha M (CD11b) assembles with integrin αbeta-2 (CD18) into a receptor known as Macrophage Antigen-1 (Mac-1) or complement receptor type 3 (CR3). This receptor binds and induces intracellular signaling through ICAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.
See all CD11b products