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COL4A1 antibody [HMV327] HistoMAX™

Recombinant antibody HistoMAX
Anti-COL4A1 antibody [HMV327] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX640559
Anti-COL4A1 antibody [HMV327] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX640559
Anti-COL4A1 antibody [HMV327] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX640559

Cat. No. GTX640559

Host

 Rabbit

Clonality

 Monoclonal

Clone Name

 HMV327

Isotype

 IgG

Application

 IHC-P

Reactivity

 Human
Package
500 μl ($649),
100 μl ($329)
See all COL4A1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:100-1:200
Not tested in other applications.

PROPERTIES

Form

Liquid

Buffer

PBS, 2% BSA

Preservative

0.025% ProClin 300

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

batch dependent

Antigen Species

Human

Immunogen

Recombinant protein encompassing a sequence within the N-terminus of human COL4A1. The exact sequence is proprietary.

Purification

Affinity purified by Protein A.

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

collagen type IV alpha 1 chain , BSVD , RATOR

Background

This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Database

Research Area

DATA IMAGES

Anti-COL4A1 antibody [HMV327] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX640559

GTX640559 IHC-P Image

IHC-P analysis of human colon descendens muscular wall tissue using GTX640559 COL4A1 antibody [HMV327] HistoMAX™.
Each smooth muscle cell is surrounded by collagen IV.

Anti-COL4A1 antibody [HMV327] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX640559

GTX640559 IHC-P Image

IHC-P analysis of human ovary corpus luteum tissue using GTX640559 COL4A1 antibody [HMV327] HistoMAX™.
Cytoplasmic collagen IV staining of corpus luteum cells, and strong staining of vessels.

Anti-COL4A1 antibody [HMV327] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX640559

GTX640559 IHC-P Image

IHC-P analysis of human pancreas tissue using GTX640559 COL4A1 antibody [HMV327] HistoMAX™.
Strong collagen IV staining of basement membranes surrounding acini.

REFERENCE

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REVIEW

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Package List Price ($)
$ 649
$ 329
Available soon.