Fas Ligand antibody [NOK-1] (PE)
Cat. No. GTX01476-08
Cat. No. GTX01476-08
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HostMouse
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ClonalityMonoclonal
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Clone NameNOK-1
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IsotypeIgG1
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ApplicationsFACS
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ReactivityHuman
Summary
The NOK-1 antibody reacts with human CD178 (Fas ligand) in both membrane bound and soluble forms. Fas ligand is a 40 kDa transmembrane glycoprotein, a member of the TNF-α family, and is expressed by activated T and NK cells, neutrophils, and monocytes. Interactions between CD178 (Fas ligand) and CD95 (Fas) induce a program of apoptosis and play a key role in immune regulation and homeostasis. The extracellular domain of human CD178 can be cleaved from the surface by matrix metalloproteinases (MMPs) resulting in a 26 kDa soluble protein.