APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
Application |
Recommended Dilution |
Assay dependent |
Not tested in other applications.
Calculated MW
Positive Control
human pancreas,mouse pancreas,rat pancreas
Product Note
This antibody was raised against human GLP1R Extracellular domain.
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
No preservative
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
2 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Synthetic peptide encompassing a sequence within the Extracellular domain human of GLP1R. The exact sequence is proprietary.
Purification
Affinity purified by Protein A.
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
glucagon like peptide 1 receptor , GLP-1 , GLP-1-R , GLP-1R
Cellular Localization
Cell membrane
Background
This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]
Database
Research Area
DATA IMAGES
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GTX638352 IHC-P Image
GLP1R antibody [HL2297] detects GLP1R protein at cell membrane and cytoplasm by immunohistochemical analysis.Sample: Paraffin-embedded mouse pancreas.GLP1R stained by GLP1R antibody [HL2297] (GTX638352) diluted at 1:2000 and competitor's antibody (ab218532) diluted at 1:2000.Antigen Retrieval: Citrate buffer, pH 6.0, 15 min *Competitor's antibody is not affiliated with GeneTex and does not endorse this product.
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GTX638352 IHC-P Image
GLP1R antibody [HL2297] detects GLP1R protein at cell membrane by immunohistochemical analysis.Sample: Paraffin-embedded human pancreas.GLP1R stained by GLP1R antibody [HL2297] (GTX638352) diluted at 1:200.Antigen Retrieval: Citrate buffer, pH 6.0, 15 min
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GTX638352 IHC-P Image
GLP1R antibody [HL2297] detects GLP1R protein at cell membrane by immunohistochemical analysis.Sample: Paraffin-embedded mouse pancreas.GLP1R stained by GLP1R antibody [HL2297] (GTX638352) diluted at 1:20000.Antigen Retrieval: Citrate buffer, pH 6.0, 15 min
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GTX638352 IHC-P Image
GLP1R antibody [HL2297] detects GLP1R protein at cell membrane by immunohistochemical analysis.Sample: Paraffin-embedded rat pancreas.GLP1R stained by GLP1R antibody [HL2297] (GTX638352) diluted at 1:200.Antigen Retrieval: Citrate buffer, pH 6.0, 15 min
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GTX638352 IHC-P Image
GLP1R antibody [HL2297] detects GLP1R protein at cell membrane by immunohistochemical analysis.Sample: Paraffin-embedded mouse pancreas.GLP1R stained by GLP1R antibody [HL2297] (GTX638352) diluted at 1:200.Antigen Retrieval: Citrate buffer, pH 6.0, 15 min
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REFERENCE
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REVIEW
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