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GTX65640-pro Image
LAG3 human Fc fusion protein (GTX65640-pro) induced dendritic cells (DC) maturation. Method: Immature DCs derived from human monocytes, resuspended at 1x106 cells/ml in complete culture medium, are incubated with LAG3 human Fc fusion protein (GTX65640)(10μg/ml), LPS (positive control, 5μg/ml) or human IgG1 (isotype-matched negative control, 10μg/ml) for 48 hours. DC maturation induced by LAG3 human Fc fusion protein or LPS is assessed by the increased expression of MHC Class II, CD80, CD83, CD86 and CD40.
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