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MCP2 antibody [35509.11]

Cat. No. GTX10391

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 35509.11

Isotype

 IgG1

Application

 WB, ELISA, Neutralizing/Inhibition

Reactivity

 Human
Package
100 μg ($399)
See all MCP2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1-2 μg/ml
ELISA 2.0 μg/ml
Neutralizing/Inhibition 1-4 μg/ml
Not tested in other applications.

Calculated MW

11 kDa. ( Note )

Product Note

Neutralizes the biological activity of recombinant human MCP-2. Shows <20% cross-reactivity with recombinant human MCP-1 and recombinant mouse MIP-1α.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

recombinant human MCP-2 expressed in E. coli.

Purification

Purified immunoglobulin

Conjugation

Unconjugated

RRID

AB_373987

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

C-C motif chemokine ligand 8 , HC14 , MCP-2 , MCP2 , SCYA10 , SCYA8

Cellular Localization

Secreted

Background

MCP2 and MCP3 are members of the C-C, or beta chemokine class. Other chemokines in this group include C10, Eotaxin, HCC1, I309, JE, MCP1, MIP1 alpha, MIP1 beta and RANTES. These chemokines act primarily as chemoattractants and antibody does not cross-react with other activate monocytes, dendritic cells, T lymphocytes, natural killer cells, B lymphocytes, basophils and eosinophils. MCP2 and MCP3 were originally identified as monocyte chemotactic proteins produced by human MG63 osteosacrcoma cells. MCP2 and MCP3 are approximately 9 kD polypeptides of 76 amino acids. MCP2 shares 62% amino acid sequence homology with MCP1, MCP3 shares 71% homology with MCP1, and MCP2 shares 58% homology with MCP3.

Database

Research Area

REFERENCE

Application Reference

Chiarini A et al. Cells 2020; 9 (6) CaSR Antagonist (Calcilytic) NPS 2143 Hinders the Release of Neuroinflammatory IL-6, Soluble ICAM-1, RANTES, and MCP-2 from Aβ-Exposed Human Cortical Astrocytes.
Application : WB
Reactivity : Human
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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399