PRODUCT
Summary
Multimeric Proteins are high activity constructs in which two trimeric TNFSF ligands are linked via the oligomeric collagen domain of ACRP30 [ACRP30headless] and therefore mimic the membrane-bound forms of the proteins.
APPLICATION
Application Note
Stimulates B cell proliferation.
Product Note
Binds to human and mouse BCMA and TACI. Binds to proteoglycans.
PROPERTIES
Form
Lyophilized powder
Buffer
Reconstitute with 100μl ddH₂O to 0.1mg/ml. Lyophilized from 0.2μm-filtered PBS with 0.5% Trehalose.
Preservative
No preservative
Storage
Store at -20ºC or below. After reconstitution, keep as concentrated solution. Aliquot and avoid freeze-thaw cycles.
Region/Sequence
N-terminal DDDDK-Tag; the extracellular domain of mouse APRIL (a.a. 88-232) is fused at the N-terminus to mouse ACRP30headless (a.a. 18-110).
Expression System
HEK293 cells
Purity
??95% by SDS-PAGE.
Endotoxin
< 0.02 EU/μg
Conjugation
Unconjugated
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET
Synonyms
tumor necrosis factor (ligand) superfamily, member 13 , 2310026N09Rik , April , Tall2 , Tnlg7b , Trdl1
Database
Research Area
REFERENCE
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REVIEW
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