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PARP antibody [HMV334] HistoMAX™

Anti-PARP antibody [HMV334] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX640566
Anti-PARP antibody [HMV334] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX640566
Anti-PARP antibody [HMV334] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX640566

Cat. No. GTX640566

Host

 Rabbit

Clonality

 Monoclonal

Clone Name

 HMV334

Isotype

 IgG

Application

 IHC-P

Reactivity

 Human
Package
500 μl ($649),
100 μl ($329)
See all PARP products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:100-1:200

Note :

IHC-P
Heat-induced antigen retrieval for 5 minutes in an autoclave at 121ºC in pH 7.8 Target Retrieval Solution buffer.
Not tested in other applications.

Calculated MW

113 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Batch dependent

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent

Antigen Species

Human

Immunogen

Recombinant protein encompassing a sequence within the center region of human PARP. The exact sequence is proprietary.

Purification

Affinity purified by Protein A.

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

poly(ADP-ribose) polymerase 1 , ADPRT , ADPRT 1 , ADPRT1 , ARTD1 , PARP , PARP-1 , PPOL , pADPRT-1

Cellular Localization

Nucleus,Nucleolus

Background

This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-PARP antibody [HMV334] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX640566

GTX640566 IHC-P Image

IHC-P analysis of human gastrointestinal stromal tumor (GIST) tissue using GTX640566 PARP antibody [HMV334] HistoMAX™.
Gastrointestinal stromal tumor (GIST) with strong PARP1 immunostaining of tumor cells.

Anti-PARP antibody [HMV334] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX640566

GTX640566 IHC-P Image

IHC-P analysis of human warthin tumor (WT) from salivary gland tissue using GTX640566 PARP antibody [HMV334] HistoMAX™.
Warthin tumor with weak to moderate PARP1 staining of tumor cells and a markedly more intense staining of associated lymphocytes.

Anti-PARP antibody [HMV334] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX640566

GTX640566 IHC-P Image

IHC-P analysis of human gastric adenocarcinoma (intestinal type) tissue using GTX640566 PARP antibody [HMV334] HistoMAX™.
Gastric adenocarcinoma (intestinal type) with strong PARP1 staining of 100% of tumor cells.

REFERENCE

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REVIEW

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Package List Price ($)
$ 649
$ 329
Available soon.