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PD-L1 antibody [H302] HistoMAX™

Recombinant antibody HistoMAX
Anti-PD-L1 antibody [H302] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639925
Anti-PD-L1 antibody [H302] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639925
Anti-PD-L1 antibody [H302] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639925
Anti-PD-L1 antibody [H302] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639925
Anti-PD-L1 antibody [H302] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639925
Anti-PD-L1 antibody [H302] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639925
Anti-PD-L1 antibody [H302] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639925
Anti-PD-L1 antibody [H302] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639925

Cat. No. GTX639925

Host

 Rabbit

Clonality

 Monoclonal

Clone Name

 H302

Isotype

 IgG

Application

 IHC-P

Reactivity

 Human
Package
500 μl ($649),
100 μl ($329)
See all PD-L1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P Assay dependent
Not tested in other applications.

Product Note

This antibody was raised against human PD-L1 Intracellular domain, and it does not cross with PD-L2 protein.

PROPERTIES

Form

Liquid

Buffer

PBS, 2% BSA

Preservative

0.025% ProClin 300

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

batch dependent

Antigen Species

Human

Immunogen

Synthetic peptide encompassing a sequence within the Intracellular domain of human PD-L1. The exact sequence is proprietary.

Purification

Affinity purified by Protein A.

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD274 molecule,B7-H,B7H1,PD-L1,PDCD1L1,PDCD1LG1,PDL1

Cellular Localization

Cell membrane

Background

This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Database

Research Area

DATA IMAGES

Anti-PD-L1 antibody [H302] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639925

GTX639925 IHC-P Image

IHC-P analysis of human oral cavity tissue using GTX639925 PD-L1 antibody [H302] HistoMAX™.
Strong predominantly membranous PD-L1 positivity of all tumor cells of a squamous cell carcinoma of the oral cavity. Some inflammatory cells are also PD-L1 positive.

Anti-PD-L1 antibody [H302] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639925

GTX639925 IHC-P Image

IHC-P analysis of human lymph node tissue using GTX639925 PD-L1 antibody [H302] HistoMAX™.
A subset of inflammatory cells stain PD-L1 positive.

Anti-PD-L1 antibody [H302] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639925

GTX639925 IHC-P Image

IHC-P analysis of human pharynx tissue using GTX639925 PD-L1 antibody [H302] HistoMAX™.
Strong membranous PD-L1 positivity of the stroma-adjacent (peripheric) tumor cell layers of a squamous cell carcinoma of the pharynx.

Anti-PD-L1 antibody [H302] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639925

GTX639925 IHC-P Image

IHC-P analysis of human thymus tissue using GTX639925 PD-L1 antibody [H302] HistoMAX™.
Moderate to strong PD-L1 staining of thymic epithelial cells. Some macrophages also stain positive.

Anti-PD-L1 antibody [H302] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639925

GTX639925 IHC-P Image

IHC-P analysis of human esophagus tissue using GTX639925 PD-L1 antibody [H302] HistoMAX™.
PD-L1 negative esophageal adenocarcinoma showing intense PD-L1 positivity of tumor adjacent macrophages.

Anti-PD-L1 antibody [H302] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639925

GTX639925 IHC-P Image

IHC-P analysis of human colon tissue using GTX639925 PD-L1 antibody [H302] HistoMAX™.
PD-L1 negative colorectal adenocarcinoma surrounded by numerous PD-L1 positive inflammatory cells.

Anti-PD-L1 antibody [H302] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639925

GTX639925 IHC-P Image

IHC-P analysis of human placenta mature tissue using GTX639925 PD-L1 antibody [H302] HistoMAX™.
Strong PD-L1 staining of the external membrane of the syncytiotrophoblast.

Anti-PD-L1 antibody [H302] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639925

GTX639925 IHC-P Image

IHC-P analysis of human ovary corpus luteum tissue using GTX639925 PD-L1 antibody [H302] HistoMAX™.
Moderate to strong membranous PD-L1 staining of corpus luteum cells.

REFERENCE

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REVIEW

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Package List Price ($)
$ 649
$ 329