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PSMA antibody [YPSMA-1]

Cat. No. GTX19071

Reference 5

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 YPSMA-1

Isotype

 IgG2b

Application

 WB, ICC/IF, IHC-P, IHC-Fr, ELISA

Reactivity

 Human
Package
250 μg ($399)
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APPLICATION

Application Note

For ELISA: Use at an assay dependent dilution. For IF: Use at an assay dependent dilution. For IHC-Fr: Use at an assay dependent dilution. For IHC-P: Use at an assay dependent dilution. For WB: Use at an assay dependent dilution. Optimal dilutions/concentrations should be determined by the researcher.

Calculated MW

84 kDa. ( Note )

Positive Control

LNCaP cell line

Product Note

Minimal or no cross-reactivity to benign prostate hyperplasia (BPH) or to normal prostatic tissue.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Crude membrane protein preparation from pooled prostate malignant carcinoma from China.

Purification

Protein G purified

Conjugation

Unconjugated

RRID

AB_423409

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

folate hydrolase 1 , FGCP , FOLH , GCP2 , GCPII , NAALAD1 , NAALAdase , PSM , PSMA , mGCP

Cellular Localization

Cell membrane

Background

This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]

Database

Research Area

REFERENCE

Application Reference

Rao S et al. Genome Med 2024; 16 (1) : 35 Intra-prostatic tumour evolution, steps in metastatic spread and histogenomic associations revealed by integration of multi-region whole-genome sequencing with histopathological features.
Tykvart J et al. Prostate 2014; (Epub) Comparative analysis of monoclonal antibodies against prostate-specific membrane antigen (PSMA).
Application : WB, IHC-P, ELISA
Reactivity : Human
Wang W et al. Urol Oncol 2009; 27 (5) : 525-8 PSMA expression in Schwannoma: a potential clinical mimicker of metastatic prostate carcinoma.
Mhawech-Fauceglia P et al. Cancer Epidemiol Biomarkers Prev 2008; 17 (3) : 571-7 Prostate-specific membrane antigen expression is a potential prognostic marker in endometrial adenocarcinoma.
Application : IHC-P
Reactivity : Human
Mhawech-Fauceglia P et al. Histopathology 2007; 50 (4) : 472-83 Prostate-specific membrane antigen (PSMA) protein expression in normal and neoplastic tissues and its sensitivity and specificity in prostate adenocarcinoma: an immunohistochemical study using mutiple tumour tissue microarray technique.
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Package List Price ($)
$ 399
Custom Conjugations