Form
Liquid
Buffer
20mM Potassium Phosphate, 150mM NaCl
Preservative
0.01% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
85 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Rb2 (p130) peptide corresponding to a region near the C-terminus of the human protein conjugated to KLH.
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
Synonyms
RB transcriptional corepressor like 2 , P130 , Rb2
Cellular Localization
Nucleus
Background
The product of the Retinoblastoma related human gene RB2 (p130) is highly homologous to the product of the Rb tumor suppressor gene, Rb (p105), especially in the functional pocket region of the protein. Certain carcinoma derived cell lines show low levels of Rbs expression, possibly due to gene rearrangement. In other experiments, a drastic reduction in proliferation is observed upon introduction of active Rb2.
Database
Research Area