SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [CR3022-RB]

Cat. No. GTX01556
Cat. No.  GTX01556
  • Host
    Rabbit
  • Clonality
    Monoclonal
  • Clone Name
    CR3022-RB
  • Isotype
    IgG
  • Applications
    ELISA Neutralizing/Inhibition
  • Reactivity
    SARS Coronavirus, SARS Coronavirus 2
Summary
This antibody binds to both SARS-CoV and SARS-CoV-2 with high affinity (PMID: 16796401 & 32065055). The initial characterization of the binding of this antibody was performed by ELISA and indicates potential for the development of diagnostic assays, as both virus-capture assays, or as controls in serological assays measuring immune responses to virus exposure. The original human IgG1 version of the antibody works synergistically in combination with another non-competing SARS antibody CR3014 and is a potential candidate for passive immune prophylaxis of SARS-CoV infection (ter Meulen et al., 2006). The original antibody (human IgG1) was also reported to bind the 2019-nCoV RBD (KD of 6.3 nM). This antibody may have potential as a therapeutic agent, alone or in combination with other neutralizing antibodies for treatment of 2019-nCoV infections (Tian et al., 2020).
See all SARS-CoV-2 (COVID-19) Spike products