SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [CR3022-RB]
Cat. No. GTX01556
Cat. No. GTX01556
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HostRabbit
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ClonalityMonoclonal
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Clone NameCR3022-RB
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IsotypeIgG
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ApplicationsELISA Neutralizing/Inhibition
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ReactivitySARS Coronavirus, SARS Coronavirus 2
Summary
This antibody binds to both SARS-CoV and SARS-CoV-2 with high affinity (PMID: 16796401 & 32065055). The initial characterization of the binding of this antibody was performed by ELISA and indicates potential for the development of diagnostic assays, as both virus-capture assays, or as controls in serological assays measuring immune responses to virus exposure. The original human IgG1 version of the antibody works synergistically in combination with another non-competing SARS antibody CR3014 and is a potential candidate for passive immune prophylaxis of SARS-CoV infection (ter Meulen et al., 2006). The original antibody (human IgG1) was also reported to bind the 2019-nCoV RBD (KD of 6.3 nM). This antibody may have potential as a therapeutic agent, alone or in combination with other neutralizing antibodies for treatment of 2019-nCoV infections (Tian et al., 2020).