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beta 2 Defensin antibody

Anti-beta 2 Defensin antibody used in IHC (Paraffin sections) (IHC-P). GTX49324
Anti-beta 2 Defensin antibody used in IHC (Paraffin sections) (IHC-P). GTX49324
Anti-beta 2 Defensin antibody used in IHC (Paraffin sections) (IHC-P). GTX49324
Anti-beta 2 Defensin antibody used in IHC (Paraffin sections) (IHC-P). GTX49324

Cat. No. GTX49324

Host

 Goat

Clonality

 Polyclonal

Isotype

 IgG

Application

 IHC-P

Reactivity

 Human
Package
100 μg ($569)
See all beta 2 Defensin products
PRODUCT

Summary

Goat polyclonal antibody to beta 2 Defensin

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P Assay dependent
Not tested in other applications.

Product Note

This antibody recognizes human Defensin beta-2 (BD-2), a ~4.|3kDa cationic antimicrobial peptide, also known as Beta-defensin 4A or Skin-antimicrobial peptide 1 (SAP-1) expressed primarily by epithelial cells of the respiratory tract and skin, and an important component of the innate immune response against microbial infections.|Expression of BD-2 is induced during inflammation in response to bacterial products and cytokines, and is initially expressed in a precursor form, which is cleaved to release the C-Terminal active portion of the protein which is secreted by the neutrophil and binds to bacterial membranes causing their disruption.

PROPERTIES

Form

Lyophilized powder

Buffer

PBS

Storage

Prior to reconstitution store at +4ºC.Following reconstitution store at -20ºC.Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

Concentration

0.1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Pig

Immunogen

Recombinant human Defensin beta-2.

Purification

Antisera to human Defensin beta 2 were raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Background

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 4, an antibiotic peptide which is locally regulated by inflammation. [provided by RefSeq, Jul 2008]

Research Area

DATA IMAGES

Anti-beta 2 Defensin antibody used in IHC (Paraffin sections) (IHC-P). GTX49324

GTX49324 IHC-P Image

IHC-P analysis of inflamed oral mucosa using beta 2 Defensin antibody.

Anti-beta 2 Defensin antibody used in IHC (Paraffin sections) (IHC-P). GTX49324

GTX49324 IHC-P Image

IHC-P analysis of inflamed oral mucosa using beta 2 Defensin antibody.

Anti-beta 2 Defensin antibody used in IHC (Paraffin sections) (IHC-P). GTX49324

GTX49324 IHC-P Image

IHC-P analysis of inflamed oral mucosa using beta 2 Defensin antibody.

Anti-beta 2 Defensin antibody used in IHC (Paraffin sections) (IHC-P). GTX49324

GTX49324 IHC-P Image

IHC-P analysis of inflamed oral mucosa using beta 2 Defensin antibody.

REFERENCE

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REVIEW

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Package List Price ($)
$ 569