Angiogenesis entails the generation of new blood vessels from pre-existing vasculature. It is an intricate process tightly regulated by input from pro- and anti-angiogenic factors. In the normal adult, the balance between these inducers and inhibitors maintains a quiescent state that nevertheless is capable of rapid changes in response to micro-environmental disruptions secondary to wounds, hypoxia, or inflammation. Perturbations of this balance in various chronic pathological conditions and tumors can lead to inappropriate angiogenesis or neovascularization. The mechanistic features underlying angiogenesis are complex, but the clinical importance of being able to modulate this process means that this will remain a compelling and dynamic field of research.

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