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Cancer Stem Cells

Cancer Stem Cells

Cancer Stem Cells
Cancer stem cells (CSCs) are increasingly being recognized as the key determinative cells of malignancies. CSCs are described as relatively quiescent cells capable of self-renewal and the generation of more differentiated daughter cells that constitute the bulk of the tumor mass. While there is still debate as to the existence of a single subset of CSCs versus a collection of CSC variants in some tumors, a growing body of literature links CSCs to all steps of tumorigenesis, from initiation to metastasis. Even more ominously, however, evidence suggests that these cells are responsible for therapeutic resistance and relapse, with their persistence often meaning a poor clinical prognosis. For these reasons, CSC biology has become a vigorously studied area of cancer research.

Cancer Stem Cells Markers

Breast Colon Glioma Liver Lung Melanoma Ovarian Pancreatic Prostate
ALDH1 ABCB5 A2B5 ALDH1 ABCG2 ABCB5 ALDH1 ABCG2 A2B1
CD24 ALDH1 CD15 CD13 ALDH1 ALDH1 CD24 ALDH1 ALDH1
CD44 CD24 CD90 CD24 CD90 CD20 CD44 CD24 CD24
CD90 CD26  CD133 CD44 CD117 CD34 CD117 CD44 CD44
CD133 CD29  α6-integrin CD90 CD133 CD117 CD133 CD133  CD133
α6-integrin CD44  Nestin CD133   CD133   c-Met  CD166
EpCAM CD133   EpCAM   CD166   CXCR4  α2β1-integrin
p63 CD166   ICAM1   CD271   Nestin  α6-integrin
  EpCAM   Sall4   Nestin   EpCAM  
  LGR5              

 

Selected Cancer Stem Cells Markers

     
ALDH1A1 antibody

ALDH1A1 antibody (GTX123973)

c-Met antibody [C3], C-term

c-Met antibody [C3], C-term (GTX100637)

  
Integrin beta 1 / CD29 antibody

Integrin beta 1 / CD29 antibody (GTX128839)

 
 
CD44 antibody [GT462]

CD44 antibody [GT462] (GTX628895)

   
CD54 / ICAM1 antibody [N1C2]

CD54 / ICAM1 antibody [N1C2](GTX100450)

CD90/Thy1 antibody

CD90/Thy1 antibody (GTX130072)

 
EpCAM antibody [N3C3]

EpCAM antibody [N3C3] (GTX113091)

Nestin antibody [GT623]

Nestin antibody [GT623] (GTX630201)

 
   
 
Pathways

Wnt Pathway

Wnt proteins are secreted morphogens that are required for various developmental processes.
Literature

Poster - Cancer Signaling

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Literature

Pamphlet - Hot Products

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Pamphlet - Antibodies for Cancer Research

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Literature

Flyer - Cancer Stem Cells

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Literature

Poster - Cancer Signaling

Download the latest version of GeneTex's cancer signaling poster
Literature

Pamphlet - Hot Products

Download the latest version of GeneTex's pamphlet of hot products.
Literature

Pamphlet - Antibodies for Cancer Research

Download the latest version of GeneTex's pamphlet of antibodies for cancer research
Literature

Flyer - Cancer Stem Cells

Download the latest version of GeneTex's cancer stem cells flyer