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Cancer Immune Checkpoints

Cancer Immune Checkpoints

Cancer Immune Checkpoints

Increasing knowledge of how cancer cells escape immune destruction has significantly driven the evolution of cancer immunotherapy. In particular, studies describing how different immune checkpoints, including the PD-1 and CTLA-4 pathways, function to attenuate T cell antitumor activity have revealed novel opportunities for therapeutic intervention. Researchers have made promising strides in inhibiting these checkpoints to unleash the T cells’ tumor-killing potential. Given that both radiotherapy and chemotherapy can also mobilize antitumor T cells, there is great excitement that checkpoint inhibition and other immunomodulatory approaches can be combined with conventional modalities to maximize clinical outcomes for a number of malignancies.

GeneTex Proudly Provides an Outstanding PD-L1 Antibody for Your Research

       
    Used at 1:1000 for IHC
    Knockout/knockdown validation
    Highly specific and sensitive
    Citation support

 

PD-L1 antibody (GTX104763)
Citation Support   KOKD Validation Comparable Abs Orthogonal Validation Protein Overexpression

 

PD-L1 antibody

KO/KD-Validated

PD-L1 antibody

IHC

PD-L1 antibody

Target Specificity

 

 

Click here to view the full list of antibodies for the study of immune checkpoints

 

Highlighted Products
Citation Support   KOKD Validation Orthogonal Validation Protein Overexpression
PD-1 antibody
(GTX20256)

PD-1 antibody
(GTX20256)

CTLA4 antibody
(GTX57204)

CTLA4 antibody
(GTX57204)

CD4 antibody
(GTX44531)

CD4 antibody
(GTX44531)

CD40 antibody
(GTX101447)

CD40 antibody
(GTX101447)

CD80 antibody
(GTX84701)

CD80 antibody
(GTX84701)

TNF alpha antibody
(GTX110520)

TNF alpha antibody
(GTX110520)

CD86 antibody
(GTX41787)

CD86 antibody
(GTX41787)

4-1BB / CD137 antibody [17B5] (FITC) (GTX43758)

4-1BB / CD137 antibody [17B5] (FITC) (GTX43758)

B7-H3 / CD276 antibody [MIH42] (PE) (GTX43126)

B7-H3 / CD276 antibody [MIH42] (PE) (GTX43126)

TIM-3 antibody
(GTX54055)

TIM-3 antibody
(GTX54055)

LAG3 antibody [C9B7W] (Low endotoxin, azide free)
(GTX42244)

LAG3 antibody [C9B7W] (Low endotoxin, azide free)
(GTX42244)

CD134 antibody
(GTX74995)

CD134 antibody
(GTX74995)

Arginase 1 antibody
(GTX109242)

Arginase 1 antibody
(GTX109242)

ICOS antibody
(GTX129570)

ICOS antibody
(GTX129570)

iNOS antibody
(GTX130246)

iNOS antibody
(GTX130246)

Literature
World Class Validated Antibodies

Brochure - World Class Validated Antibodies

Download the latest version of GeneTex's World Class Validated Antibodies brochure.
Pathways

Wnt Pathway

Wnt proteins are secreted morphogens that are required for various developmental processes.
Literature

Poster - Cancer Signaling

Download the latest version of GeneTex's cancer signaling poster
Literature

Pamphlet - Hot Products

Download the latest version of GeneTex's pamphlet of hot products.
Literature

Pamphlet - Antibodies for Cancer Research

Download the latest version of GeneTex's pamphlet of antibodies for cancer research
Literature

Flyer - Cancer Immune Checkpoints

Download the latest version of GeneTex's cancer immune checkpointss flyer
Literature
World Class Validated Antibodies

Brochure - World Class Validated Antibodies

Download the latest version of GeneTex's World Class Validated Antibodies brochure.
Literature

Poster - Cancer Signaling

Download the latest version of GeneTex's cancer signaling poster
Literature

Pamphlet - Hot Products

Download the latest version of GeneTex's pamphlet of hot products.
Literature

Pamphlet - Antibodies for Cancer Research

Download the latest version of GeneTex's pamphlet of antibodies for cancer research
Literature

Flyer - Cancer Immune Checkpoints

Download the latest version of GeneTex's cancer immune checkpointss flyer