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Tumor Suppressor Proteins

Tumor Suppressor Proteins

Tumor Suppressor Proteins

Tumor suppressor gene products, or tumor suppressor proteins, act as barriers to block cells from proceeding down the path to cancer. In contrast to the protein products of proto-oncogenes, some tumor suppressor proteins act to restrain abnormal cell proliferation. Others promote cell death pathways or function in DNA repair. While mutated proto-oncogenes behave in a dominant fashion, tumor suppressor genes are generally recessive, thus requiring that both be inactivated or otherwise compromised in order for cancers to occur. Well-described examples of tumor suppressor proteins include RB, p53, APC and CDKN2A/p14 ARF.

Highlighted Products
Citation Support KOKD Validation IP/MS Analysis Orthogonal Validation Protein Overexpression

 

Oncoproteins: Growth Factors and Receptors

p53 antibody [DO1]

p53 antibody [DO1]
(GTX70214)

Rb antibody

Rb antibody
(GTX100545)

CDKN2A / p14ARF antibody

CDKN2A / p14ARF antibody
(GTX129902)

 
BRCA1 antibody [17F8] - ChIP grade

BRCA1 antibody [17F8] - ChIP grade
(GTX70111)

BRG1 antibody [GT2712]

BRG1 antibody [GT2712]
(GTX633391)

SMAD2 antibody

SMAD2 antibody
(GTX111131)

 
Pathways

Wnt Pathway

Wnt proteins are secreted morphogens that are required for various developmental processes.
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Poster - Cancer Signaling

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Pamphlet - Hot Products

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Pamphlet - Antibodies for Cancer Research

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