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Histone Modifications

Histone Modifications

The nucleosome core particle is the fundamental structural unit of the eukaryotic genome. It consists of a histone octamer composed of two H2A-H2B dimers and a H3-H4 tetramer wrapped by ~146 base pairs of DNA. A linker histone (i.e., H1) associates with the nucleosomal dyad as well as with linker DNA on either side of the nucleosome, resulting in the formation of the chromatosome. All the core and linker histones are post-translationally decorated, with at least 160 total modifications described to date including acetylation, methylation, phosphorylation, propionylation, citrullination, formylation, proline isomerization, butyrylation, ADP ribosylation, ubiquitylation, sumoylation, and the more recently identified glycosylation and crotonylation. These modifications are thought to impact chromatin functions by either altering chromatin packaging or through the recruitment/inhibition of specific chromatin binding factors. Thus, the combined signal from a particular collection of histone marks constitutes a “histone code” that affects gene expression or other chromatin-based functions.

Highlighted Products

     

Histone H1 Antibodies

Histone H1.0 antibody (GTX114462)

 

Histone H1.2 antibody (GTX122561)

 

Histone H1S35ph (phospho Ser35) antibody (GTX121669)

 
 
 

Histone H2A Antibodies

Histone H2A antibody (GTX129418)

Histone H2A.X antibody (GTX108272)

 

Histone H2A.X (phospho Ser139) antibody (GTX628789)

 
 
 

Histone H2B Antibodies

5-Methylcytosine / 5-mC antibody [GT4111] (GTX629448)

 

5-Methylcytosine/ 5-mC antibody (GTX128455)

5-HydroxymethylCytidine antibody [GT13612] (GTX629765)

 
 
 

 

Histone H3 Antibodies

Histone H3 antibody (GTX122148)

 

Histone H3K4me2 (dimethyl Lys4) antibody (GTX121915)

Histone H3K27me3 (Tri-methyl Lys27) antibody (GTX121184)

 
 
 

 

Histone H4 Antibodies

Histone H3 antibody (GTX122148)

 

Histone H3K4me2 (dimethyl Lys4) antibody (GTX121915)

Histone H3K27me3 (Tri-methyl Lys27) antibody (GTX121184)

 
 
 

Histone Modifying Enzyme Antibodies

Histone H3 antibody (GTX122148)

 

Histone H3K4me2 (dimethyl Lys4) antibody (GTX121915)

 

Histone H3K27me3 (Tri-methyl Lys27) antibody (GTX121184)

 

Histone H3 antibody (GTX122148)

 

Histone H3K4me2 (dimethyl Lys4) antibody (GTX121915)

 

Histone H3K27me3 (Tri-methyl Lys27) antibody (GTX121184)

 
 
 
Literature

Flyer - Epigenetics Histone Modification

Download the latest version of GeneTex's epigenetics histone modification flyer.
Literature

Pamphlet - Hot Products

Download the latest version of GeneTex's pamphlet of hot products.
Literature

Flyer - Epigenetics Histone Modification

Download the latest version of GeneTex's epigenetics histone modification flyer.
Literature

Pamphlet - Hot Products

Download the latest version of GeneTex's pamphlet of hot products.