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DNA Methylation

The mammalian TET proteins (Ten Eleven Translocation) encode 5-methylcytosine (5-mC) dioxygenases. There are three TETs in human: TET1, TET2, and TET3. These TET proteins convert 5-mC to 5-hydroxymethylcytosine (5-hmC) and subsequently to 5-formylcytosine (5-fC) and 5-carboxylcytosine (5-caC). This series of modifications is thought to represent one pathway to active DNA demethylation, thereby reshaping the methylated DNA landscape established by DNA methyltransferases (DNMTs). In addition, these marks, particularly 5-hmC, have been shown to be distinct epigenetic signatures in their own right impacting stem cell and cancer cell biology. TET proteins have also been shown to be components of crosstalk mechanisms between DNA and histone modifications that determine gene expression status. Thus, within the span of a few years, the TET proteins have become recognized as central players in gene regulation, pluripotency, cell differentiation, and carcinogenesis. It is clear that researchers have crossed a threshold into an exciting new realm of epigenetics research, with countless discoveries waiting to be made. GeneTex is proud to introduce a selection of its antibodies to targets relevant to DNA methylation and demethylation, histone modification, and cell pluripotency. Many of the antibodies are suitable for IP/ChIP applications.

Highlighted Products

      

TET Antibodies

TET1 antibody (GTX627420)

TET1 antibody
(GTX627420)

  
TET2 antibody (GTX124205)

TET2 antibody
(GTX124205)

TET3 antibody
(GTX121453)

TET3 antibody
(GTX121453)

 
 
 

DNMT Antibodies

DNMT1 antibody
(GTX116011)

DNMT1 antibody
(GTX116011)

 
DNMT3A antibody
(GTX129125)

DNMT3A antibody
(GTX129125)

 
DNMT3B antibody
(GTX129127)

DNMT3B antibody
(GTX129127)

   
 
 

5-mC, 5-hmC and 5-caC Antibodies

5-Methylcytosine / 5-mC antibody (GTX629448)

5-Methylcytosine / 5-mC antibody (GTX629448)

 
5-Methylcytosine/ 5-mC antibody (GTX128455)

5-Methylcytosine/ 5-mC antibody (GTX128455)

5-HydroxymethylCytidine antibody (GTX629765)

5-HydroxymethylCytidine antibody (GTX629765)

 

 

Literature
World Class Validated Antibodies

Brochure - World Class Validated Antibodies

Download the latest version of GeneTex's World Class Validated Antibodies brochure.
Literature
Epigenetics poster

Poster - Epigenetics

Download the latest version of GeneTex's Epigenetics poster
Literature

Flyer - Epigenetics DNA Methylation

Download the latest version of GeneTex's epigenetics DNA methylation flyer.
Literature

Pamphlet - Hot Products

Download the latest version of GeneTex's pamphlet of hot products.
Literature
World Class Validated Antibodies

Brochure - World Class Validated Antibodies

Download the latest version of GeneTex's World Class Validated Antibodies brochure.
Literature
Epigenetics poster

Poster - Epigenetics

Download the latest version of GeneTex's Epigenetics poster
Literature

Flyer - Epigenetics DNA Methylation

Download the latest version of GeneTex's epigenetics DNA methylation flyer.
Literature

Pamphlet - Hot Products

Download the latest version of GeneTex's pamphlet of hot products.