Endoplasmic Reticulum

The endoplasmic reticulum (ER) is a eukaryotic membranous organelle consisting of flattened, connected sacs (cisternae) that is responsible for synthesis of membrane and secretory proteins and their subsequent proper folding and posttranslational decoration. It can be divided into two distinct types: rough endoplasmic reticulum (RER) and smooth endoplasmic reticulum (SER). The RER is studded with ribosomes to synthesize membrane and secreted proteins and has some continuity with the nuclear membrane lumen. No ribosomes are associated with the SER, which is involved in lipid metabolism. Soluble proteins are transported from the ER to the Golgi apparatus by way of vesicles for further modification, and are subsequently released from the Golgi in vesicles destined to fuse with the cell membrane. ER quality control mechanisms are triggered when accumulation of unfolded or misfolded proteins is detected by various sensors, including PERK, IRE1, and ATF6. ER stress is associated with a variety of conditions including cancer, diabetes, inflammatory diseases, and neurodegenerative disorders.

GeneTex is proud to offer an outstanding selection of antibodies for endoplasmic reticulum research. These antibodies are validated for various applications and are an important component of our reagent catalog supporting studies of organelle proteins. Please see the highlighted products below.

Highlighted Products