Kidney- Desmin negative clear cell renal cell carcinoma.

Liver- Desmin negative cholangiocellular carcinoma.

Oral cavity- Desmin negative squamous cell carcinoma invading desmin positive fibres of skeletal muscle.

Ovary- Malignant mixed Mullerian tumor showing desmin immunostaining of a sarcomatoid tumor component.

Pharynx- Desmin negative squamous cell carcinoma invading desmin positive skeletal muscle fibres.

Prostate- Desmin negative adenocarcinoma (Gleason 3+3=6). Smooth muscle cells of the prostatic stroma show strong desmin positivity.

Soft tissue- Liposarcoma exhibiting a weak to moderate desmin immunostaining of a small fraction of tumor cells (<3%).

Soft tissue- Liposarcoma showing a moderate desmin positivity of a fraction of tumor cells.

Soft tissue- Rhabdomyosarcoma showing strong diffuse desmin immunostaining.

Soft tissue- Strong diffuse desmin positivity of all tumor cells of a rhabdomyosarcoma.

Stomach- Desmin negative gastrointestinal stromal tumor (GIST).

Stomach- Diffuse type gastric adenocarcinoma invading desmin positive smooth muscle fibres.

Stomach- Gastric adenocarcinoma (diffuse type) invading desmin positive smooth muscle fibres.

Stomach- Gastric adenocarcinoma (intestinal type) invading desmin positive smooth muscle fibres.

Testis- Desmin negative seminoma.

Thyroid- Desmin negative papillary carcinoma.

Urinary bladder- Desmin negative muscle-invasive urothelial carcinoma. Desmin immunostaining delineates elements of the muscular bladder wall.

Urinary bladder- Desmin negative small cell carcinoma invading desmin positive smooth muscle fibres of the tunica muscularis.

Urinary bladder- Desmin negative urothelial carcinoma. Desmin immunostaining highlights elements of the muscular bladder wall invaded by the tumor.

Uterus- Leiomyoma showing strong desmin immunostaining.

Uterus- Leiomyosarcoma exhibiting strong desmin positivity.

Uterus- Leiomyosarcoma with moderate to strong desmin positivity.