Adrenal gland

Adrenal gland

Aorta, media

Appendix, mucosa

Appendix, muscular wall

Bone marrow

Breast

Bronchus, mucosa

cerebellum (molecular layer, Purkinje cell layer, granule cell layer)

cerebellum (molecular layer, Purkinje cell layer, granule cell layer, white matter)

Cerebrum, grey matter

Cerebrum, white matter

Colon descendens, mucosa: In the colon mucosa, variable levels of TIM-3 immunostaining are seen in T-cells and in macrophages. Epithelial staining does not occur.

Colon descendens, muscular wall

Duodenum, Brunner gland

Duodenum, mucosa

Ectocervix

Endocervix

Endometrium, proliferation

Endometrium, secretion

Epididymis: A strong TIM-3 staining occurs at the apical membranes an ciliae of tall columnar cells of the epididymis.

Esophagus, squamous epithelium

Esophagus, squamous epithelium

Fat

Gallbladder, epithelium

heart

Ileum, mucosa: A membranous TIM-3 immunostaining of the surface epithelium of the small intestine may represent a (tolerable) cross-reactivity.

Ileum, mucosa

Kidney, cortex: In the kidney, apical membranes of a fraction of proximal tubuli show a moderate TIM-3 immunostaining.

Kidney, medulla

Liver: TIM-3 immunostaining occurs in venous sinusoids of the spleen and in Kupffer cells of the liver.

Lung: In the lung, a particularly strong TIM-3 immunostaining occurs in alveolar macrophages.

lymph node: In the lymph node, TIM-3 expression is seen in subsets of T-lymphocytes and macrophages. In this sample, macrophages show a particularly strong TIM-3 positivity.

Ovary, stroma

Pancreas

Parathyroid

Parotid gland

Pituitary gland, anterior lobe

Pituitary gland, anterior lobe

Pituitary gland, posterior lobe

Pregnant uterus (decidua): Numerous interspersed macrophages show a strong TIM-3 immunostaining.

Placenta, early: In placenta macrophages, a strong TIM-3 immunostaining is seen.

Placenta, mature

Placenta, mature

Prostate

Rectum, mucosa

Seminal vesicle

Sinus paranasales

Skin: In the skin, TIM-3 immunostaining occurs in a fraction of T-lymphocytes and of macrophages.

Spleen: In the spleen, TIM-3 immunostaining occurs in venous sinusoids as well as in T-lymphocytes.

Stomach, antrum

Stomach, corpus

Striated muscle

Testis

Thymus: In the thymus, TIM-3 immunostaining is rarely seen in cortical T-cells.

Thyroid gland

Tonsil: In the tonsil, variable levels of TIM-3 immunostaining are seen in T-cells and in macrophages.

Tonsil, surface epithelium: In the tonsil surface epithelium, TIM-3 immunostaining occurs in a fraction of T-lymphocytes and of macrophages. The black staining of the surface mebrane represents an inking effect.

Urinary bladder, muscular wall

Urinary bladder, urothelium

Uterus, myometrium