Adrenal gland

Aorta, media

Appendix, mucosa – Topoisomerase II alpha positive cells in the appendix mucosa reflect proliferating cells.

Appendix, muscular wall

Bone marrow

Breast

Bronchus, mucosa

Cerebellum (molecular layer, Purkinje cell layer, granule cell layer)

Cerebellum (molecular layer, Purkinje cell layer, granule cell layer, white matter)

Cerebrum, grey matter

Cerebrum, white matter

Colon descendens, muscular wall

Colon, mucosa

Duodenum, Brunner gland

Duodenum, mucosa

Epididymis

Esophagus, squamous epithelium

Fallopian tube, mucosa

Fat

Gallbladder, epithelium

Heart muscle

Ileum, mucosa – Topoisomerase II alpha positive cells in the ileum mucosa reflect proliferating cells.

Kidney, cortex

Kidney, cortex

Liver

Lung

Lymph node

Ovary, stroma

Pancreas

Parathyroid gland

Parotid gland

Pituitary gland, anterior lobe

Pituitary gland, posterior lobe

Placenta (amnion and chorion)

Placenta, early

Pregnant uterus (decidua)

Placenta, mature

Prostate

Rectum, mucosa

Seminal vesicle

Sinus paranasales, epithelium

Skeletal muscle

Skin – Topoisomerase II alpha immunostaining is seen seen in proliferating cells.

Spleen

Stomach, antrum – Topoisomerase II alpha positive cells in the stomach antrum reflect proliferating cells.

Stomach, corpus – Topoisomerase II alpha positive cells in the stomach corpus reflect proliferating cells.

Testis – Spermatocyte of the testis – subject to meiosis – is the only normal cell type with a consistent strong Topoisomerase II alpha expression in virtually all cells.

Thymus – The highest rate of Topoisomerase II alpha positive lymphocytes is seen in the thymus (cortex).

Thyroid gland

Tonsil – In the tonsil, Topoisomerase II alpha positive lymphocytes are predominantly seen in germinal centres.

Tonsil, surface epithelium – In the tonsil, Topoisomerase II alpha immunostaining can regularly be seen in epithelial cells and lymphocytes with a distribution pattern consistent with proliferating cells.

Urinary bladder, muscular wall

Urinary bladder, urothelium

Uterus, ectocervix – Few proliferating cells show Topoisomerase II alpha immunostaining.

Uterus, endocervix

Uterus, endometrium (proliferation)

Uterus, endometrium (secretion)

Uterus, myometrium