Ion channels are pore-forming, usually multimeric plasma membrane proteins that can open and close in response to chemical, temperature, or mechanical signals. An open channel allows specific ions to rapid ly traverse the transmembrane passageway a long an electrochemical gradient, generating an electrical signal that is propagated along excitable cells. Ion channels are of immense importance in clinical medicine as they are linked to a broad array of disorders and are targets of an ever-expanding, and commonly prescribed, armamentarium of pharmacologic agents. Nevertheless, there remains a great void in our understanding of ion channel biology, which limits our ability to develop more effective and mo re specific drugs.

GeneTex offers an outstanding selection of antibodies to support ion channel research.Please see the highlighted antibodies in this flyer or review our complete list of related products on the GeneTex website.

 

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HCN1 antibody (GTX131334) IHC-Fr (left; Green) and IHC-P (right) analysis of HCN1 expression in mouse cerebellum.

DPP6 antibody (GTX133338) IHC-Fr (left; Green) and IHC-P (right) analysis of DPP6 expression in mouse hippocampus.

IP3 Receptor I antibody (GTX133104) IHC-Fr (left; Green) and IHC-P (right) analysis of IP3 Receptor I expression in mouse cerebellum.

CACNB4 (GTX100202) IHC-Fr (left; Green) and IHC-P (right) analysis of CACNB4 expression in mouse cerebellum.

VGluT1 antibody (GTX133148) IHC-Fr (left; Green) and IHC-P (right) analysis of VGluT1 expression in mouse cerebellum.

P2X7 antibody (GTX104288) IHC-Fr (left; Green) and IHC-P (right) analysis of P2X7 expression in mouse retina (left) and rat brain (right).

 

Cav1.2 antibody (GTX54754) IHC analysis of Cav1.2 (red) and Calbindin 28K (green) expression in mouse cerebellum.

Cav2.1 antibody (GTX54753) IHC analysis of Cav2.1 (red) and GFAP (green) expression in mouse cerebellum.

Cav3.1 antibody (GTX54760) IHC analysis of Cav3.1 expression (green) and DAPI (blue) in rat cerebellum.

 

Cav3.2 antibody (GTX54813) IHC analysis of Cav3.2 expression (red) and parvalbumin staining (green) in mouse cerebellum.

TRPV1 antibody (GTX54762) IHC analysis of TRPV1 expression (red) and parvalbumin staining (green) in rat dorsal root ganglion.

TRPC6 antibody (GTX54757) IHC analysis of TRPC6 expression (red) and parvalbumin staining (green) in mouse cerebellum.

 

Nav1.6 antibody (GTX54842) IHC analysis of Nav1.6 expression (green), parvalbumin staining (red) and DAPI (blue) in mouse hippocampus.

ASIC1 antibody (GTX54804) IHC analysis of ASIC1 expression (red) and parvalbumin staining (green) in rat brain.

ASIC3 antibody (GTX54807) IHC-Fr analysis of ASIC3 (red) and ASIC1 (green) expression with DAPI (blue) in rat dorsal root ganglia.