Adrenal gland – Adrenocortical adenoma with a weak to moderate , mostly membranous Synaptophysin immunostaining in about 50% of tumor cells.

Adrenal gland – Adrenocortical adenoma with a weak Synaptophysin immunostaining in few tumor cells.

Adrenal gland – Moderate to strong Synaptophysin positivity in an adrenocortical adenoma.

Adrenal gland – Pheochromocytoma with strong, diffuse Synaptophysin positivity in all tumor cells.

Breast – Invasive breast cancer of no special type (NST) exhibiting a weak to moderate Synaptophysin immunostaining of all tumor cells.

Breast – Synaptophysin negative invasive breast cancer of no special type (NST).

Lung – Small cell carcinoma showing a moderate Synaptophysin immunostaining of all tumor cells.

Lung – Synaptophysin negative adenocarcinoma.

Pancreas – Neuroendocrine tumor exhibiting strong cytoplasmic Synaptophysin immunostaining of tumor cells.

Prostate – Synaptophysin negative adenocarcinoma (Gleason 3+3=6).

Prostate – Synaptophysin positive adenocarcinoma (Gleason 5+5=10).

Retroperitoneum – Diffuse, moderate to strong Synaptophysin immunostaining of all cells of a leiomyosarcoma.

Skin – Merkel cell carcinoma displaying an intense cytoplasmic Synaptophysin immunostaining of all tumor cells.

Skin – Synaptophysin negative basal cell carcinoma.

Stomach – Synaptophysin negative adenocarcinoma (intestinal type).

Thyroid – Medullary carcinoma with strong cytoplasmic synaptophysin immunostaining of all tumor cells.

Urinary bladder – Small cell carcinoma with diffuse, intense cytoplasmic Synaptophysin positivity.