Adrenal gland – A strong synaptophysin immunostaining regularly occurs in the medulla of the adrenal gland. Some cortical cells may show weak to moderate staining.

Adrenal gland – A weak to moderate synaptophysin immunostaining can be found in a subset of cells of the adrenal cortex.

Aorta, media

Appendix, mucosa – In the appendix, synaptophysin immunostaining is limited to neuroendocrine cells and nerve fibres.

Appendix, muscular wall

Bone marrow

Breast

Bronchus, mucosa

Cerebellum (molecular, granular and Purkinje layers; white matter) – Synaptophysin is strongly expressed in the cerebellum.

Cerebrum, grey matter – Synaptophysin is strongly expressed in the cerebrum.

Colon descendens, muscular wall

Colon descendes, mucosa – Strong synaptophysin immunostaining in neuroendocrine cells of the mucosa, nerve fibres and ganglion cells of the submucosa.

Duodenum, Brunner gland

Duodenum, mucosa – In the small intestine, synaptophysin immunostaining is seen in neuroendocrine cells and in goblet cells.

Epididymis

Esophagus, squamous epithelium

Fallopian tube, mucosa

Fat

Gallbladder, epithelium

Heart muscle

Ileum, mucosa – In the small intestine, synaptophysin immunostaining is seen in neuroendocrine cells and in goblet cells.

Kidney, cortex

Kidney, medulla

Liver – In the liver, synaptophysin positive nerve fibres are seen in portal fields.

Lung

Lymph node

Ovary, stroma – A few nerve fibres occur in the ovarian stroma.

Pancreas – A strong synaptophysin immunostaining is seen in islet cells of Langerhans.

Parathyroid gland

Parotid gland – Small synaptophysin positive nerve fibres are present in the parotid gland.

Pituitary gland, posterior lobe – Strong synaptophysin immunostaining in the neurohypophysis.

Pituitary gland, anterior lobe – Strong synaptophysin immunostaining in all epithelial cells of the adenohypophysis.

Placenta (amnion and chorion)

Pregnant uterus (decidua)

Placenta (first trimenon)

Placenta, mature

Prostate

Rectum, mucosa – In the rectum mucosa, synaptophysin immunostaining is seen in neuroendocrine cells and nerve fibres.

Seminal vesicle

Sinus paranasales

Skeletal muscle

Skin

Spleen

Stomach, antrum – Neuroendocrine cells show synaptophysin immunostaining in the stomach.

Stomach, corpus – Neuroendocrine cells show synaptophysin immunostaining in the stomach.

Stomach, corpus – Neuroendocrine cells show synaptophysin immunostaining in the stomach. In some samples, a fraction of glandular cells may show weak cytoplasmic staining.

Testis

Thymus

Thyroid gland – In the thyroid, synaptophysin immunostaining is limited to C-cells which are not seen on all tissue spots.

Thyroid gland – Strong synaptophysin immunostaining occurs in C-cells of the thyroid.

Tonsil, surface epithelium

Tonsil

Urinary bladder, muscular wall

Urinary bladder, urothelium

Uterus, ectocervix

Uterus, endocervix

Uterus, endometrium (proliferation)

Uterus, endometrium (secretion)

Uterus, myometrium