The voltage-gated potassium (Kv) channel Kv1.3 mediates K⁺ flux but also functions in protein:protein interaction-mediated cell signaling that underlies various pathological processes. Identifying the Kv1.3 interactome could pinpoint new targets for therapeutic intervention. In their recent work, Prosdocimi et al. used BioID proximity labeling to reveal some of these KV1.3-associating proteins involved in tumorigenesis and discovered a KV1.3-STAT3-p53 signaling axis that promotes tumor progression (1). Blocking expression of Kv1.3 significantly reduced cell proliferation, tumor size, and metastasis. Collectively, this study reveals the critical role of Kv1.3 in cancer biology and suggests a general experimental approach to discover the Kv1.3 interactomes responsible for its other actions.

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JNK (phospho Thr183/Tyr185) antibody [HL1008] GTX635799	PARP antibody [HL1364] GTX636804	EGFR (phospho Tyr1148) antibody [HL3278] GTX640932	STAT3 (phospho Tyr705) antibody [HL1464] GTX636938

  

Reference:

1. Sci Adv. 2024 Sep 6;10(36):eadn9361. doi: 10.1126/sciadv.adn9361.