Adrenal gland – A variable intensity MCM3 immunostaining occurs in a fraction of adrenal cells

Aorta, media

Appendix, mucosa – A strong MCM3 immunostaining is seen in crypt cells of the appendical mucosa. Many lymphocytes are also positive

Appendix, muscular wall – Some smooth muscle cells exhibit a faint MCM3 staining. A moderate to strong MCM3 also occurs in some other cell types

Bone marrow – A strong MCM3 immunostaining occurs in the majority of bone marrow cells

Breast – A weak to moderate MCM3 staining occurs in many luminal cells

Bronchus, mucosa

Cerebellum (granule cell layer, white matter)

Cerebellum (molecular layer, Purkinje cell layer, granule cell layer)

Cerebrum, grey matter

Cerebrum, white matter

Colon descendens, mucosa – A strong MCM3 immunostaining is seen in crypt cells

Colon descendens, muscular wall

Duodenum, Brunner gland

Duodenum, Mucosa – A strong MCM3 immunostaining occurs in duodenal crypt cells

Epididymis – A weak to moderate MCM3 staining occurs in most basal cells and also many principal cells of the corpus epididymis

Esophagus, squamous epithelium – Esophageal squamous epithelium exhibits a moderate to strong MCM3 immunostaining of suprabasal and basal cells

Fallopian tube, mucosa – MCM3 staining in a significant fraction of epithelial cells

Fat

Gallbladder, epithelium – The number of MCM3 positive cells is variable in the gallbladder epithelium

Heart muscle – A faint MCM3 staining can be seen in some heart muscle cells

Ileum, mucosa – A strong MCM3 immunostaining is seen in crypt cells of the ileum

Kidney, cortex – Only few cells show MCM3 immunostaining in the kidney

Kidney, medulla

Liver – A variable intensity MCM3 immunostaining can be seen in a small fraction of hepatocytes

Lung

Lymph node – Many lymphocytes are MCM3 positive. A particularly strong MCM3 positivity occurs in most cells of germinal centres and also in scattered individual cells of the interfollicular zone

Ovary, stroma – A faint MCM3 staining can be seen in ovarian stroma cells

Pancreas – A variable intensity MCM3 immunostaining occurs in a small fraction of pancreatic epithelial cells. The rate of positive cells is particularly low in islets of Langerhans

Parathyroid gland – A variable intensity MCM3 immunostaining can be seen in a fraction of parathyroideal cells

Parotid gland – variable intensity MCM3 immunostaining can be seen in a fraction of epithelial cells

Pituitary gland, anterior lobe

Pituitary gland, posterior lobe

Placenta (amnion and chorion)

Placenta, early – Many cells of the cytotrophoblast and a fraction of stroma cells show strong MCM3 staining

Placenta, mature – Cells of the cytotrophoblast and a fraction of stroma cells show strong MCM3 staining

Prostate – Only very few acinar cells show MCM3 positivity. MCM3 positivity rather occurs in basal cells

Rectum, mucosa – A strong MCM3 immunostaining is seen in crypt cells

Seminal vesicle

Sinus paranasales – MCM3 immunostaining occurs in a fraction of respiratory epithelial cells

Skin – In the squamous epithelium of the skin, suprabasal and (weaker) basal cell layers show a distinct MCM3 immunostaining

Spleen – Most lymphocytes of the white pulp are MCM3 positive. A strong MCM3 positivity also occurs in scattered individual cells of all compartments

Stomach, antrum – A strong MCM3 immunostaining occurs in mucous neck cells of the stomach

Stomach, corpus – A strong MCM3 immunostaining occurs in mucous neck cells of the stomach

Striated muscle – A weak to moderate MCM3 staining occurs in some skeletal muscle cells

Testis – Most spermatocytes are strongly MCM3 positive but mature sperms and probably also spermatogonia are negative

Thymus – A particularly strong MCM3 positivity occurs in most cells of the thymic cortex

Thyroid gland – A variable intensity MCM3 immunostaining can be seen in a small fraction of follicular cells in the thyroid

Tonsil – In the tonsil, a large fraction of lymphocytes is at least weakly MCM3 positive. A particularly strong MCM3 positivity occurs in most cells of germinal centres and also in individual cells of the interfollicular zone.

Tonsil, surface epithelium – The squamous epithelium shows a moderate to strong MCM3 immunostaining of suprabasal and basal cells. Many lymphocytes are also positive

Urinary bladder, muscular wall

Urinary bladder, urothelium – Only few urothelial cells show a MCM3 immunostaining

Uterus, ectocervix – The squamous epithelium shows a moderate MCM3 immunostaining of (mostly) suprabasal cells

Uterus, endocervix – Epithelial cells of the endocervix show a particularly low rate of MCM3 positive cells

Uterus, endometrium (pregnancy)

Uterus, endometrium (proliferation) – Almost all epithelial cells and a fraction of stromal cells are MCM3 positive

Uterus, endometrium (secretion) – The fraction of MCM3 positive epithelial cells is lower in the secretion phase

Uterus, myometrium – A faint MCM3 immunostaining can be observed in some muscle cells