Obesity

Obesity

Obesity is characterized by increased lipid accumulation in adipocytes, leading to white adipose tissue hypertrophy, impaired lipolysis, and ectopic fat deposition in other tissues. Adipocytes are also highly active secretory cells, producing proteins and hormones that function well beyond metabolism. The worldwide epidemic of obesity has led to a dramatic increase in metabolic diseases, including type 2 diabetes mellitus, nonalcoholic fatty liver disease, steatohepatitis, asthma, cancer, cardiovascular disease, and neurodegenerative diseases that are related to the generation of low‑grade, chronic inflammation. Type 2 diabetes is caused by obesity-driven insulin resistance in white adipose tissue, the liver, and skeletal muscle combined with impaired secretion of insulin by pancreatic β-cells. Understanding the molecular mechanisms that promote obesity-related diseases will accelerate the development of new therapeutic approaches for these often devastating conditions.

GeneTex is proud to offer an outstanding selection of antibodies to study adipogenesis, adipocyte biology, and insulin resistance signaling for obesity research. These antibodies are validated for various applications to facilitate your efforts in this exciting field. Please see the highlighted products below.

Highlighted Products