Glutamic acid decarboxylase (GAD) catalyzes the decarboxylation of glutamate to generate gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter controlling neuronal excitability. In humans, GAD is expressed by two independently regulated genes (GAD1 and GAD2) to produce two isoforms: GAD67 (67 kDa) and GAD65 (65 kDa), respectively. GAD67 and GAD65 share high protein homology, and both are targeted to mark GABAergic neurons. However, though they both perform the same enzymatic reaction, they have different functional roles and produce GABA in distinct cellular locations (1).

GeneTex is proud to offer newly launched recombinant rabbit monoclonal antibodies that detect GAD67 alone, GAD65 alone, or both isoforms for many applications and species. Please see the highlighted product data images and table below and visit www.genetex.com for more details.

 

Highlighted Products

GAD65 antibody [HL1187] (GTX636493)

GAD67 antibody [HL1095] (GTX636279)

GAD67 antibody [HL1096] (GTX636280)

GAD65 + GAD67 antibody [HL1181] (GTX636487)

 

Cat. No. Product Name Host & Clonality Reactivity Applications GTX636493 GAD65 antibody [HL1187] Rec Rb mAb Hu, Ms, Rat, Zfsh, Cat, Dog WB, ICC/IF, IHC-P GTX636279 GAD67 antibody [HL1095] Rec Rb mAb Hu, Ms, Rat, Cat, Dog WB, ICC/IF, IHC-P GTX636280 GAD67 antibody [HL1096] Rec Rb mAb Hu, Ms, Rat, Zfsh, Cat, Dog WB, IHC-P GTX636487 GAD65 + GAD67 antibody [HL1181] Rec Rb mAb Hu, Ms, Rat, Zfsh, Cat, Dog WB, ICC/IF, IHC-P

 

Reference:

1. Front Endocrinol (Lausanne). 2022; 13: 972115.