Figure 1. The VEEV virion

 

Venezuelan equine encephalitis virus (VEEV) is one of the three major encephalitic alphaviruses (the others being Eastern Equine Encephalitis Virus (EEEV) and Western Equine Encephalitis Virus (WEEV)) that can cause severe illness in humans. VEEV infects both equids and humans in a geographical distribution that includes Mexico to northern South America. As an arbovirus, VEEV is primarily transmitted by hematophagous insects, including mosquitoes, and most frequently causes a mild flu-like syndrome in humans. However, neurologic complications can occur in nearly 15% of cases, with case fatality rates that can be almost 10%. Presently, there is no available vaccine for widespread use and no medical treatment but supportive care. The potential for VEEV and other alphaviruses to be weaponized remains a significant concern (1).

VEEV is an enveloped virus with a single-stranded, positive-sense RNA genome that codes for four nonstructural (nsP1-nsP4) and six structural proteins (1). As part of its efforts to generate the most comprehensive line of reagents for infectious disease research, GeneTex is proud to offer new recombinant rabbit monoclonal antibodies against the VEEV nonstructural proteins (see “Highlighted Products” below). These antibodies are exciting additions to GeneTex’s expanding portfolio of reagents for arbovirus research (which includes antibodies against Zika virus, Chikungunya virus, Dengue virus, and Japanese encephalitis virus, among others). Please see the highlighted product images and a complete VEEV antibody listing below.

Figure 2. The VEEV genomic organization

 

Highlighted Products

Venezuelan Equine Encephalitis Virus nsP1 antibody [HL1472] (GTX636946)	Venezuelan Equine Encephalitis Virus nsP2 antibody [HL1919] (GTX637668)
Venezuelan Equine Encephalitis Virus nsP3 antibody [HL1502] (GTX636976)	Venezuelan Equine Encephalitis Virus nsP4 antibody [HL1741] (GTX637389)

 

Cat. No. Product Name Clonality Applications GTX636946 Venezuelan Equine Encephalitis Virus nsP1 antibody [HL1472] Rec Rb mAb WB, ICC/IF, IHC-P (cell pellet) GTX637072 Venezuelan Equine Encephalitis Virus nsP1 antibody [HL1593] Rec Rb mAb WB, IHC-P (cell pellet) GTX637668 Venezuelan Equine Encephalitis Virus nsP2 antibody [HL1919] Rec Rb mAb WB, ICC/IF GTX636976 Venezuelan Equine Encephalitis Virus nsP3 antibody [HL1502] Rec Rb mAb WB, ICC/IF, IHC-P (cell pellet) GTX636978 Venezuelan Equine Encephalitis Virus nsP3 antibody [HL1504] Rec Rb mAb WB GTX637389 Venezuelan Equine Encephalitis Virus nsP4 antibody [HL1741] Rec Rb mAb WB, ICC/IF

 

 

Reference:

1. Viruses. 2023 Jan 28;15(2):382.doi: 10.3390/v15020382.