PIEZO ion channels (PIEZO1 and PIEZO2) are mechanosensitive signaling receptors expressed in mammalian intestinal stem cells (ISCs). Understanding their roles in transduction of extrinsic signals in ISCs is an important area of research into the dynamics of the intestinal crypt microenvironment.

 

In a new study published in Science, Baghdadi et al. implement various strategies to show that the PIEZO receptors are intimately involved in ISC self-renewal and lineage determination (1). The authors show Piezo gene conditional knockout in mouse models resulted in self-renewal and lineage defects as well as lethality. They also reveal differential levels of stiffness in the crypt, and that stiffness shapes ISC behavior through PIEZO. These findings support further research into ISC PIEZO receptor functions in ageing, repair, and inflammatory processes.

 

GeneTex offers an extensive catalog of quality antibodies for stem cell research, including the MUC2 antibody (GTX100664) cited in this study and two new MUC2 recombinant monoclonal antibodies (see below). In addition, GeneTex provides extensively validated recombinant rabbit monoclonal antibodies for cell biology research. For more information, please see the product data images below and visit www.genetex.com.

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Reference:

Science. 2024 Nov 29; 386(6725):eadj7615. DOI: 10.1126/science.adj7615