The concept of a SARS-CoV-2 / COVID-19 rapid test

Diagnostic and screening tests that combine simplicity, speed, and reliable, clear readouts are essential tools in clinical settings. Specific analytes in a sample, such as pathogens or biomarkers, can be detected by lateral flow assay. Lateral flow assays are generally very easy to use and provide rapid information as to the presence or absence of a given analyte in a biological sample.

 

Most of COVID-19 rapid tests utilize sandwich immunoassay technology, which detects SARS-CoV-2 particles in samples by capturing viral antigen between a free labeled antibody and a fixed second antibody that each recognize different regions of the antigen. On the other hand, a rapid anti-virus IgM/IgG test uses a similar approach to detect human IgM and IgG antibodies that are reactive to SARS-CoV-2. This provides crucial information related to whether a patient has been exposed to the virus and where they are temporally in the clinical course of the disease. Please see Table 1 and Figure 1 for specific details.

 

Table 1. COVID-19 Rapid Tests

Assay Type

Detection Target

Reagents Used in the Test

Clinical Significance

Rapid virus antigen test

SARS-CoV-2 nucleocapsid/spike protein

Nucleocapsid protein antibodies/spike protein antibodies

Ongoing viral production

Rapid anti-virus IgM/IgG test

Anti-SARS-CoV-2 IgM and IgG antibodies

(1) Anti-human IgM and anti-human IgG antibodies
(2) Labeled viral antigen (spike/nucleocapsid protein)

Assessment of patient’s immune response to past or ongoing viral infection

Figure 1: Relationship between the amount/type of antibody generated against SARS-CoV-2 and the clinical stage of COVID-19 disease.
(In some young people or special conditions, IgM may appear on the fourth day.)

How do COVID-19 Rapid Tests Work?

COVID-19 rapid test strips contain a control line to confirm the test is working properly along with one or two test lines. Analyte detection is qualitative and read visually. Below are links to two animated videos detailing the components inside the rapid test devices and how they interact with one another to produce the colored results.

 

  1. SARS-CoV-2 rapid virus antigen test: Please click on link (https://youtu.be/PkczTPfIE20). Possible result readouts are shown in Figure 2 below.

 

 

Figure 2: Possible result readouts of a SARS-CoV-2 rapid virus antigen test.

2. SARS-CoV-2 rapid anti-virus IgM/IgG test: Please click on link (https://youtu.be/bAHFylmV5D8). Possible result readouts are shown in Figure 3.

 

 

Figure 3: Possible result readouts of a SARS-CoV-2 rapid anti-virus IgM/IgG test.

GeneTex is proud to offer an extensive line of reagents to support the study of SARS-CoV-2/COVID-19. Please see Table 2Table 3, and Table 4 below to view listings of GeneTex's antibodies, recombinant proteins, and cell pellet blocks available now to accelerate your SARS-CoV-2/COVID-19 research. 

 

Table 2. Antibodies for SARS-CoV-2 / COVID-19 Research

Clonality

Cat. No.

Product Name

Host

Applications

Recombinant

 

 

   

 

 

 

 

       

GTX635656

SARS-CoV-2 (COVID-19) Spike S1 antibody [HL1]

Rabbit

WB, ICC/IF, ELISA, sELISA

GTX635671

SARS-CoV-2 (COVID-19) Spike S1 antibody [HL134]

Rabbit

WB, ICC/IF, ELISA

GTX635672

SARS-CoV-2 (COVID-19) Spike S1 antibody [HL263]

Rabbit

WB, ICC/IF, ELISA

GTX635654

SARS-CoV-2 (COVID-19) Spike S1 antibody [HL6]

Rabbit

WB, ICC/IF, ELISA, sELISA

GTX635680

SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL146]

Rabbit

WB, ICC/IF, ELISA

GTX635678

SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL249]

Rabbit

WB, ICC/IF, ELISA

GTX635679

SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL344]

Rabbit

WB, ICC/IF, ELISA

GTX635685

SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL5410]

Rabbit

WB, ELISA, sELISA

GTX635686

SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL448]

Rabbit

WB, ELISA

GTX635687

SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL453]

Rabbit

WB, ELISA

GTX635688

SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL455]

Rabbit

WB, ELISA

GTX635689

SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL5511]

Rabbit

WB, ELISA

GTX01555

SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [CR3022]

Human

ELISA, Neutralizing/Blocking

GTX01556

SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [CR3022-RB]

Rabbit

ELISA, Neutralizing/Blocking

Monoclonal

   
GTX632604 SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [1A9] Mouse WB, ICC/IF, IHC-P, FACS, IP, ELISA, sELISA
GTX632269 SARS-CoV / SARS-CoV-2 (COVID-19) nucleocapsid antibody [6H3] Mouse WB, ICC/IF, IHC-P, IP, ELISA, sELISA
GTX632602 SARS-CoV / SARS-CoV-2 (COVID-19) ORF7a antibody [3C9] Mouse WB, ICC/IF
GTX632696 SARS-CoV / SARS-CoV-2 (COVID-19) NSP8 antibody [5A10] Mouse WB
Polyclonal         GTX135384 SARS-CoV-2 (COVID-19) Spike S1 antibody Rabbit  WB, ICC/IF
GTX135386 SARS-CoV-2 (COVID-19) Spike S2 / S2' antibody Rabbit WB, ICC/IF, ELISA, sELISA
GTX135385 SARS-CoV-2 (COVID-19) Spike RBD antibody Rabbit WB, ICC/IF
GTX135356  SARS-CoV-2 (COVID-19) Spike antibody  Rabbit WB, ICC/IF, IHC-P, ELISA
GTX135360 SARS-CoV-2 (COVID-19) Spike antibody  Rabbit WB, ICC/IF, ELISA, sELISA
GTX135357 SARS-CoV-2 (COVID-19) nucleocapsid antibody  Rabbit WB, ICC/IF, IHC-P, IP, ELISA, sELISA
GTX135361  SARS-CoV-2 (COVID-19) nucleocapsid antibody  Rabbit WB, ICC/IF, IHC-P, ELISA, sELISA
GTX101395 ACE2 antibody [N1N2], N-term  Rabbit  WB, IHC-P, FACS, ELISA
GTX100743 TMPRSS2 antibody [N2C3]  Rabbit  WB, IHC-P

Table 3. Recombinant Proteins for SARS-CoV-2 / COVID-19 Research

Cat. No.

Product Name

GTX01554-pro

SARS-CoV-2 (COVID-19) Spike S1 protein, His tag (active)

GTX01548- pro

SARS-CoV-2 (COVID-19) Spike S1 protein, His and Avi tag (active)

GTX135684-pro

SARS-CoV-2 (COVID-19) Spike S2 (ECD) protein, mouse IgG Fc tag

GTX01546-pro

SARS-CoV-2 (COVID-19) Spike RBD protein, His tag (active)

GTX135357-pro

SARS-CoV-2 (COVID-19) nucleocapsid protein, His tag

GTX135592-pro

SARS-CoV-2 (COVID-19) nucleocapsid protein, His tag
GTX01547-pro SARS-CoV-2 (COVID-19) Envelope protein, His and Avi tag
GTX135648-pro SARS-CoV-2 (COVID-19) 3C-like Proteinase protein, His tag
GTX01557-pro SARS-CoV-2 (COVID-19) 3C-like Proteinase protein, His and Avi tag

Table 4. Cell Pellet Blocks for SARS-CoV-2 / COVID-19 Research

Cat. No.

Product Name

GTX435640

SARS-CoV-2 (COVID-19) Spike FFPE 293T cell pellet block

GTX435643

SARS-CoV-2 (COVID-19) Spike S1 FFPE 293T cell pellet block

GTX435644

SARS-CoV-2 (COVID-19) Spike S2 FFPE 293T cell pellet block

GTX435641

SARS-CoV-2 (COVID-19) Nucleocapsid FFPE 293T cell pellet Block

GTX435645

SARS-CoV-2 (COVID-19) Membrane FFPE 293T cell pellet Block

GTX435642

SARS-CoV-2 (COVID-19) Envelope FFPE 293T cell pellet Block