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ACE antibody [M4110421]

Cat. No. GTX22092

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 M4110421

Isotype

 IgM

Application

 IHC-P, IHC-Fr, FACS, ELISA

Reactivity

 Human, Mouse, Bovine
Package
50 μg ($419)
See all ACE products

APPLICATION

Application Note

ELISA: Use at an assay dependent dilution. FACS: Use at an assay dependent dilution. IHC-P: Use at an assay dependent dilution. IHC-Fr: Use at an assay dependent dilution. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

150 kDa. ( Note )

Product Note

Shown to crossreact with human, bovine and mouse Angiotensin Converting Enzyme and Endothelial cells.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.65 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Human Angiotensin Converting Enzyme

Purification


Purified by PEG precipitation.

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

angiotensin I converting enzyme , ACE1 , CD143 , DCP , DCP1

Cellular Localization

Cytoplasm

Background

This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq, May 2010]

Database

Research Area

REFERENCE

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REVIEW

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SDS
PBS.pdf
Package List Price ($)
$ 419
Custom Conjugations