APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
Application |
Recommended Dilution |
Assay dependent |
Assay dependent |
Assay dependent |
Assay dependent |
Not tested in other applications.
Calculated MW
Positive Control
Hodgkin's lymphoma
Product Note
GTX23193 reacts with both Bcl-XS and Bcl-XL proteins.
PROPERTIES
Form
Liquid
Buffer
BSA
Preservative
Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
Antigen Species
Human
Immunogen
A synthetic peptide, aa 3-14 (Cys-QSNRELVVDFLS) of human Bcl-X protein. This amino acid sequence is shared by human and murine Bcl-X protein.
Purification
Unpurified
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
BCL2 like 1 , BCL-XL/S , BCL2L , BCLX , Bcl-X , PPP1R52
Cellular Localization
Mitochondrion outer membrane,Mitochondrion matrix,Cytoplasm, cytosol
Background
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. [provided by RefSeq, Dec 2015]
Database
Research Area
DATA IMAGES
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GTX23193 IHC-P Image
Formalin-fixed, paraffin-embedded human Hodgkins lymphoma stained with GTX23193 using peroxidase-conjugate and AEC chromogen. Note cell membrane staining of Reed-Sternberg cells.
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REFERENCE
There are currently no references for Bcl-X antibody [2H12] (GTX23193). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for Bcl-X antibody [2H12] (GTX23193). Be the first to share your experience with this product.