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CD63 antibody

Anti-CD63 antibody used in IHC (Paraffin sections) (IHC-P). GTX17441
Anti-CD63 antibody used in Western Blot (WB). GTX17441
Anti-CD63 antibody used in Western Blot (WB). GTX17441

Cat. No. GTX17441

Reference 14

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human, Mouse, Rat
Package
100 μl ($399)
See all CD63 products

APPLICATION

Application Note

WB: 1:500 - 1:2000, IHC: 1:50 - 1:200

Calculated MW

26 kDa. ( Note )

Product Note

CD63 (K156) pAb detects endogenous levels of CD63 protein.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide, corresponding to amino acids 153-203 of Human CD63.

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Purity

The purity is > 95% (by SDS-PAGE).

Conjugation

Unconjugated

RRID

AB_2887563

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD63 molecule , LAMP-3 , ME491 , MLA1 , OMA81H , TSPAN30

Cellular Localization

Cell membrane , Lysosome membrane

Background

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012]

Database

Research Area

DATA IMAGES

Anti-CD63 antibody used in IHC (Paraffin sections) (IHC-P). GTX17441

GTX17441 IHC-P Image

Immunohistochemistry (IHC) analyzes of CD63 pAb in paraffin-embedded human lung carcinoma tissue.

Anti-CD63 antibody used in Western Blot (WB). GTX17441

GTX17441 WB Image

Western blot (WB) analysis of CD63 pAb at 1:500 dilution Lane1:HEK293T cell lysate Lane2:Raw264.7 cell lysate Lane3:H9C2 cell lysate

Anti-CD63 antibody used in Western Blot (WB). GTX17441

GTX17441 WB Image

The data was published in the 2022 in Bioeng Transl Med. PMID: 35600663

REFERENCE

Application Reference

Nguyen HT et al. Front Oncol 2024; 14 : 1346312 Extracellular vesicles derived from SARS-CoV-2 M-protein-induced triple negative breast cancer cells promoted the ability of tissue stem cells supporting cancer progression.
Lin A et al. J Diabetes Investig 2023; 14 (10) : 1160-1171 LINC01705 derived from adipocyte exosomes regulates hepatocyte lipid accumulation via an miR-552-3p/LXR axis.
YH Yang et al. J Ethnopharmacol 2023; : 116784 GuiLu-ErXian Glue extract promotes mesenchymal stem cells (MSC)-Induced chondrogenesis via exosomes releases and delays aging in the MSC senescence process
Application : WB
Reactivity : Human
Lin Z et al. Int J Mol Sci 2023; 24 (24) Therapeutic Potential of Adipose-Derived Stem Cell-Conditioned Medium and Extracellular Vesicles in an In Vitro Radiation-Induced Skin Injury Model.
Wakao S et al. Cell Mol Life Sci 2022; 79 (11) : 542 Phagocytosing differentiated cell-fragments is a novel mechanism for controlling somatic stem cell differentiation within a short time frame.
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REVIEW

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Application Reference
Nguyen HT et al. Front Oncol 2024; 14:1346312 Extracellular vesicles derived from SARS-CoV-2 M-protein-induced triple negative breast cancer cells promoted the ability of tissue stem cells supporting cancer progression.
Lin A et al. J Diabetes Investig 2023; 14 (10):1160-1171 LINC01705 derived from adipocyte exosomes regulates hepatocyte lipid accumulation via an miR-552-3p/LXR axis.
YH Yang et al. J Ethnopharmacol 2023;:116784 GuiLu-ErXian Glue extract promotes mesenchymal stem cells (MSC)-Induced chondrogenesis via exosomes releases and delays aging in the MSC senescence process
Application : WB
Reactivity : Human
Lin Z et al. Int J Mol Sci 2023; 24 (24) Therapeutic Potential of Adipose-Derived Stem Cell-Conditioned Medium and Extracellular Vesicles in an In Vitro Radiation-Induced Skin Injury Model.
Wakao S et al. Cell Mol Life Sci 2022; 79 (11):542 Phagocytosing differentiated cell-fragments is a novel mechanism for controlling somatic stem cell differentiation within a short time frame.
Ge Gao et al. Am J Cancer Res 2022; 12 (5):1934-1959 Circ_0006790 carried by bone marrow mesenchymal stem cell-derived exosomes regulates S100A11 DNA methylation through binding to CBX7 in pancreatic ductal adenocarcinoma.
Application : WB
Reactivity : Human
Hong Fan et al. Bioeng Transl Med 2022; 7 (2):e10287 Exosomes derived from olfactory ensheathing cells provided neuroprotection for spinal cord injury by switching the phenotype of macrophages/microglia.
Application : WB
Reactivity : Rat
Adam Matejovi? et al. FEBS Open Bio 2021; 11 (2):482-493 Comparison of separation methods for tissue-derived extracellular vesicles in the liver, heart, and skeletal muscle.
Application : WB
Reactivity : Mouse
Liu YM et al. Eur J Clin Microbiol Infect Dis 2020; (Epub) miR-1975 serves as an indicator of clinical severity upon influenza infection.
Application : WB
Reactivity : Human
Liu YM et al. J Biomed Sci 2019; 26 (1):58 Exosome-delivered and Y RNA-derived small RNA suppresses influenza virus replication.
Application : WB
Reactivity : Human
Lee HY et al. Oncotarget 2018; 9 (17):13193-13205 EIF3C-enhanced exosome secretion promotes angiogenesis and tumorigenesis of human hepatocellular carcinoma.
Application : WB
Reactivity : Human
Yen EY et al. Am J Cancer Res 2017; 7 (11):2199-2208 Exosomal TGF-β1 is correlated with lymphatic metastasis of gastric cancers.
Application : WB
Reactivity : Human
Wills C.M. et al. Front. Neurosci. 2017; (Epub) A Refined Bead-Free Method to Identify Astrocytic Exosomes in Primary Glial Cultures and Blood Plasma.
Application : WB
Reactivity : Mouse
Povero D et al. PLoS One 2014; 9 (12):e113651 Circulating extracellular vesicles with specific proteome and liver microRNAs are potential biomarkers for liver injury in experimental fatty liver disease.
Application : WB
Reactivity : Mouse
SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399