APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| Assay dependent |
| Assay dependent |
| Assay dependent |
|
Note :
Sandwich ELISA
Capture : GTX44154, Detection : GTX44158
|
Not tested in other applications.
Calculated MW
Product Note
Does not cross react with human leukocytes in cytofluorometry.Staining in immunohistochemistry:Brightness 80Cytoplasmic Staining 3+Membrane Staining 2+Background 2+Staining of Mucus 2+
PROPERTIES
Form
Liquid
Buffer
10mM Tris, 150mM NaCl
Preservative
0.05% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
Concentration
7.70 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Human natural tumor-derived purified CEA antigen.
Purification
Purified by Ion Exchange Chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
carcinoembryonic antigen related cell adhesion molecule 1 , BGP , BGP1 , BGPI
Cellular Localization
Cell membrane , Apical cell membrane , Cell junction , Secreted
Background
This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010]
Database
Research Area
REFERENCE
There are currently no references for CEACAM1 antibody [B459M] (GTX44158). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for CEACAM1 antibody [B459M] (GTX44158). Be the first to share your experience with this product.
