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United States (US)

CXCR4 peptide

Cat. No. GTX27877

Application

 Neutralizing/Inhibition

Species

 Human
Package
50 μg ($139)
See all CXCR4 products

APPLICATION

Application Note

The peptide is used for blocking the activity of anti-CXCR4 (GTX22090).Incubating the peptide with equal volume of antibody for 30 min at 37ºC usually completely blocksthe activity of anti-CXCR4 (EL) in Western blotting.

PROPERTIES

Form

Liquid

Buffer

PBS, 0.1% BSA

Preservative

0.02% Sodium azide

Storage

Store the peptide at -20ºC, stable for one year.

Concentration

0.20 mg/ml (Please refer to the vial label for the specific concentration.)

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

C-X-C Motif Chemokine Receptor 4 , Cd184 , D2S201E , Fb22 , Hm89 , Hsy3Rr , Lap-3 , Lap3 , Lcr1 , Lestr , Npy3R , Npyr , Npyrl , Npyy3R , Whim , Whims , Cxcr4

Background

CXCR4 (fusin, LESTR or HUMSTR) is a principal coreceptor for T-cell tropic strains of HIV-1 fusion and entry of human white blood cells. CXCR4 is also required for the infection by dual-tropic strains of HIV-1 and mediates CD4 independent infection by HIV-2. The a-chemokine SDF-1 is the ligand for CXCR4 and prevents infection by T-tropic HIV-1. CXCR4 associates with the surface CD4-gp120 complex before HIV enters target cells. CXCR4 messenger RNA levels correlated with HIV-1 permissiveness in diverse human cell types. Antibodies to CXCR4 block HIV-1 and HIV-2 fusion and infection of human target cells. The amino-terminal domain and the second extracellular loop of CXCR4 serve as HIV biding sites.CXCR4 is highly expressed in brain and heart, and in white blood cells, vascular endothelial cells, and umbilical cord endothelial cells.

Research Area

REFERENCE

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 139