Form
Liquid
Buffer
PBS, 0.1% BSA
Preservative
0.02% Sodium azide
Storage
Store the peptide at -20ºC, stable for one year.
Concentration
0.20 mg/ml (Please refer to the vial label for the specific concentration.)
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
Synonyms
Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Gamma , Amcbx1 , Fip-3 , Fip3 , Fip3P , Ikk-Gamma , Ikkap1 , Ikkg , Imd33 , Ip , Ip1 , Ip2 , Ipd2 , Nemo , Zc2Hc9 , Ikbkg
Cellular Localization
Cytoplasmic and Nuclear
Background
Pro inflammatory cytokines activate the transcription factor NF kappa B by stimulating the activity of a protein kinase that phosphorylates Ikappa B, an inhibitor of NF kappa B, at sites that trigger its ubiquitination and degradation. A large, cytokine responsive Ikappa B kinase (IKK) complex has been purified and the genes encoding 2 of its subunits have been cloned. These subunits, IKK alpha and Ikk beta, are protein kinases whose function is needed for NF kappa B activation by pro inflammatory stimuli. IKK is composed of similar amounts of IKK alpha, Ikk beta, which are differentially processed forms of a third subunit, IKK gamma. Ikk gamma interacts preferentially with IKK beta and is required for the activation of the IKK complex.
Research Area