APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
Application |
Recommended Dilution |
Assay dependent |
Assay dependent |
Note :
FACS
2 μg/5x10⁵ cells/test
|
Not tested in other applications.
Calculated MW
Product Note
The molecular weight of the recognized antigen is 150 kDa. CD49d antigen is the integrin alpha-4 chain non-covalently associated with the integrin beta-1-chain (CD29 molecule) forming the VLA4 complex. Reacts with monocytes, T cells, B cells, thymocytes and Langerhans cells.
PROPERTIES
Form
Liquid
Buffer
PBS, 0.1% BSA
Preservative
No preservative
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
Concentration
0.20 mg/ml (Please refer to the vial label for the specific concentration.)
Immunogen
M Leukemia Line
Purification
Purified IgG
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
integrin subunit alpha 4 , CD49D , IA4
Cellular Localization
Membrane; Single-pass type I membrane protein
Background
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Database
Research Area
REFERENCE
There are currently no references for Integrin alpha 4 antibody [HP2.1] (GTX44185). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for Integrin alpha 4 antibody [HP2.1] (GTX44185). Be the first to share your experience with this product.