APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
Application |
Recommended Dilution |
1 μg/mL |
5 μg/mL |
Assay dependent |
Not tested in other applications.
Calculated MW
Positive Control
Mouse Kidney Tissue Lysate(GTX27936)
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
LZTR2 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human LZTR2.The immunogen is located within the last 50 amino acids of LZTR2.
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
SEC16 homolog B, endoplasmic reticulum export factor , LZTR2 , PGPR-p117 , RGPR , RGPR-p117 , SEC16S
Cellular Localization
Endoplasmic reticulum membrane,Golgi apparatus membrane
Background
LZTR2, also known as RGPR-p117, is a member of the BTB-kelch superfamily and was initially described as a nuclear factor I (NFI) binding protein and transcriptional regulator of the regucalcin gene. LZTR2 is cytoplasmically localized but is thought to translocate to the nucleus, a process mediated by protein kinase C signaling following hormonal stimulation. Recent evidence has suggested that there is a strong correlation of single nucleotide polymorphisms of LZTR2 with obesity in the Japanese population similar to that seen with the TMEM18 gene and the GNPDA2, BDNF, FAIM2, and MC4R genes with obesity in Caucasian populations, suggesting LZTR2 may play a role in metabolism and obesity risk.
Database
Research Area
DATA IMAGES
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GTX85204 IHC-P Image
IHC-P analysis of mouse kidney tissue using GTX85204 LZTR2 antibody. Working concentration : 20 μg/ml
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GTX85204 WB Image
WB analysis of mouse kidney tissue lysate using GTX85204 LZTR2 antibody. Working concentration : 1 μg/ml
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GTX85204 IHC-P Image
IHC-P analysis of mouse kidney tissue using GTX85204 LZTR2 antibody. Working concentration : 5 μg/ml
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REFERENCE
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REVIEW
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