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Thyroid Hormone Receptor beta antibody

Anti-Thyroid Hormone Receptor beta antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX16393
Anti-Thyroid Hormone Receptor beta antibody used in Western Blot (WB). GTX16393

Cat. No. GTX16393

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF

Reactivity

 Human, Mouse, Rat, Sheep
Package
100 μl ($399)
See all Thyroid Hormone Receptor beta products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500 - 1:2000
ICC/IF 1:50 - 1:200
Not tested in other applications.

Calculated MW

53 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human THRB (NP_000452.2).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

thyroid hormone receptor beta , C-ERBA-2 , C-ERBA-BETA , ERBA2 , GRTH , NR1A2 , PRTH , THR1 , THRB1 , THRB2

Cellular Localization

Nucleus

Background

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-Thyroid Hormone Receptor beta antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX16393

GTX16393 ICC/IF Image

ICC/IF analysis of U2OS cells using GTX16393 Thyroid Hormone Receptor beta antibody.
Blue : DAPI
Dilution : 1:100

Anti-Thyroid Hormone Receptor beta antibody used in Western Blot (WB). GTX16393

GTX16393 WB Image

WB analysis of various sample lysates using GTX16393 Thyroid Hormone Receptor beta antibody. The signal was developed with ECL plus-Enhanced.
Dilution : 1:1000
Loading : 25μg per lane

REFERENCE

Application Reference

Steinhauser CB et al. Domest Anim Endocrinol 2021; 77 : 106632 Maternal nutrient restriction alters thyroid hormone dynamics in placentae of sheep having small for gestational age fetuses.
Application : WB
Reactivity : Sheep
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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399