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Thyroid Hormone Receptor beta (cleaved Arg327) antibody

Anti-Thyroid Hormone Receptor beta (cleaved Arg327) antibody used in Western Blot (WB). GTX86914

Cat. No. GTX86914

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB

Reactivity

 Human
Package
100 μg ($399)
See all Thyroid Hormone Receptor beta products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500~1:1000
Not tested in other applications.

Calculated MW

53 kDa. ( Note )

Product Note

Thyroid Hormone Receptor beta (cleaved Arg327) antibody detects endogenous levels of fragment of activated THRB resulting from cleavage adjacent to Arg327.

PROPERTIES

Form

Liquid

Buffer

PBS, 150mM NaCl, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

The antiserum was produced against synthesized peptide derived from human Thyroid Hormone Receptor beta (278-327).

Purification

Purified by antigen-affinity chromatography
From serum

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

CERBA2 , CERBABETA , ERBA2 , GRTH , NR1A2 , PRTH , THR1 , THRB , THRB1 , THRB2 , thyroid hormone receptor beta , Thyroid Hormone Receptor beta , thyroid hormone receptor, beta

Cellular Localization

Nucleus

Background

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-Thyroid Hormone Receptor beta (cleaved Arg327) antibody used in Western Blot (WB). GTX86914

GTX86914 WB Image

WB analysis of Jurkat cells treated with etoposide 25uM 24H using GTX86914 Thyroid Hormone Receptor beta (cleaved Arg327) antibody.

REFERENCE

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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399